G. P. Cook

Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition

This study shows CD146/MCAM has both pro- and anti-tumour roles in breast cancer due to its heterogeneous expression and link to epithelial to mesenchymal transition.

Negative regulation of p53 by the poliovirus receptor PVR is a target of a human cytomegalovirus immune evasion molecule

The paper shows that HCMV evades immune surveillance by retaining PVR intracellularly, preventing p53 induction and allowing infected cells to avoid immune and p53-mediated detection.

Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase Lck

This study uses molecular dynamics simulations to show that Lck interacts with PIP lipids in both open and closed conformations, suggesting lipid interactions regulate its conformation and T cell signaling.

TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells

This study shows TGFβ suppresses Myc-driven metabolic changes in CD8+ T cells during activation by blocking amino acid uptake and glycolysis, while sparing mitochondrial respiration and mTOR activation.

Multi-scale simulations of the T cell receptor reveal its lipid interactions, dynamics and the arrangement of its cytoplasmic region

This study uses multi-scale simulations to investigate TCR-CD3 conformational dynamics, cytoplasmic tail arrangement, and lipid interactions, revealing their role in T cell activation.

The CXCR6/CXCL16 axis links inflamm-aging to disease severity in COVID-19 patients

This study examines the role of the CXCR6/CXCL16 axis in severe COVID-19, finding elevated CD8+CXCR6+ T cells with age and increased CXCL16 levels in severe cases.

Oncolytic virus treatment differentially affects the CD56dim and CD56bright NK cell subsets in vivo and regulates a spectrum of human NK cell activity

This study shows reovirus treatment affects CD56dim and CD56bright NK cell subsets differently, modulating their activity and signaling pathways in vivo.

Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered natural killer cell phenotype in glioblastoma

CD99 regulates cancer cell transendothelial migration and endothelial cell function via CDC42 and actin remodelling

This study shows CD99 regulates cancer cell transendothelial migration and endothelial function through CDC42 and actin remodeling in breast and prostate cancer.

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

The paper identifies M2-N31 inhibitors that show synergistic antiviral effects when combined with existing drugs, offering a strategy to combat rimantadine-resistant influenza.