Author

R. J. Unwalla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Han· 2 shared A. Dermenci· 1 shared A. Flick· 1 shared A. H. Varghese· 1 shared A. Maxwell· 1 shared A. Thorarensen· 1 shared A.-M. Dechert Schmidt· 1 shared B. J. Hogan· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

S. Han

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Author profile →

2 papers

Recent·Most cited

Structural basis for CCR6 modulation by allosteric antagonists

D. J. Wasilko, B. S. Gerstenberger, K. A. Farley, W. Li, J. Alley, M. E. Schnute, R. J. Unwalla, J. Victorino, K. K. Crouse, R. Ding, P. V. Sahasrabudhe, F. Vincent, R. K. Frisbie, A. Dermenci, A. Flick, , H. Wu

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.

bioRxiv · Apr 5, 2024Biochemistry

An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism

J. A. Lees, J. M. Dias, F. Rajamohan, J.-P. Fortin, R. O'Connor, J. X. Kong, E. Hughes, E. L. Fisher, J. B. Tuttle, G. Lovett, B. L. Kormos, R. J. Unwalla, L. Zhang, A.-M. Dechert Schmidt, D. Zhou, , S. Han

The paper reports the first structural characterization of GPR61 and identifies a potent inverse agonist, revealing an allosteric mechanism.

bioRxiv · May 1, 2023 · PreprintBiophysics