Author

E. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Approach:deep learning· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Bermudez· 1 shared A. H. Varghese· 1 shared A. Kerr· 1 shared A. Maxwell· 1 shared A. Uus· 1 shared A.-M. Dechert Schmidt· 1 shared B. G. Bryne· 1 shared B. L. Kormos· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperCancer Biology

A. Bermudez

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Author profile →

6 papers

Recent·Most cited

Asynchronous microexon splicing of LSD1 and PHF21A during neurodevelopment

M. Nagai, R. S. Porter, E. Hughes, T. Saunders, S. Iwase

The paper shows that PHF21A microexon expression precedes LSD1 microexon expression during neurodevelopment, leading to stepwise deactivation of the LSD1-PHF21A complex and unique gene-regulatory roles in neurons.

bioRxiv · Mar 21, 2024Biochemistry

Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry

S. M. Pearsall, S. C. Williamson, F. J. Garcia Marques, S. Humphrey, E. Hughes, Y. T. Shue, A. Bermudez, K. Frese, M. Galvin, M. Carter, L. Preist, A. Kerr, C. Zhou, T. G. Oliver, J. D. Humphries, , C. Dive

This study identifies VM-competent non-neuroendocrine cells in SCLC that support vessel formation and tumor growth through integrin β1-dependent ECM remodeling.

Journal of Thoracic Oncology · Oct 1, 2023Peer-reviewedCancer Biology

An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism

J. A. Lees, J. M. Dias, F. Rajamohan, J.-P. Fortin, R. O'Connor, J. X. Kong, E. Hughes, E. L. Fisher, J. B. Tuttle, G. Lovett, B. L. Kormos, R. J. Unwalla, L. Zhang, A.-M. Dechert Schmidt, D. Zhou, , S. Han

The paper reports the first structural characterization of GPR61 and identifies a potent inverse agonist, revealing an allosteric mechanism.

bioRxiv · May 1, 2023 · PreprintBiophysics

SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity

M. Manali, L. A. Bissett, J. Amat, N. Logan, S. Scott, E. Hughes, W. Harvey, R. Orton, E. Thomson, R. Gunson, M. Viana, B. Willett, P. R. Murcia

The paper examines how SARS-CoV-2 evolution and patient immunological history influence antibody breadth and potency against different variants.

bioRxiv · May 6, 2022Microbiology

3D UNet with GAN discriminator for robust localisation of the fetal brain and trunk in MRI with partial coverage of the fetal body

A. Uus, I. Grigorescu, M. van Poppel, E. Hughes, J. Steinweg, T. Roberts, D. Lloyd, K. Pushparajah, M. Deprez

This paper proposes a 3D UNet with a GAN discriminator to accurately localize the fetal brain and trunk in MRI scans with partial body coverage.

bioRxiv · Jun 23, 2021 · PreprintBioengineering

A Two-Component System that Modulates Cyclic-di-GMP Metabolism Promotes Legionella pneumophila Differentiation and Viability in Low-Nutrient Conditions

E. Hughes, B. G. Bryne, M. S. Swanson

This paper identifies a two-component system regulating cyclic-di-GMP metabolism in L. pneumophila that promotes differentiation and survival in low-nutrient conditions.

bioRxiv · Apr 11, 2019Microbiology