Author

J. M. Dias

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:batch correction / integration· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

J.-P. Fortin· 2 shared S. Han· 2 shared A. H. Varghese· 1 shared A. I. Teixeira· 1 shared A. M. Mathiowetz· 1 shared A. Maxwell· 1 shared A. R. Saxena· 1 shared A. S. Kalgutkar· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

J.-P. Fortin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Biodistribution of DNA-origami nanostructures in live zebrafish embryos with single-cell resolution

C. Kolonelou, L. Bräutigam, S. Edwards, E. Engström, J. M. Dias, J. Spratt, C. Karampelias, S. Wennmalm, H. Brismar, O. Andersson, A. I. Teixeira

This study tracks DNA-origami nanostructures in zebrafish embryos using imaging and single-cell RNA sequencing to understand their biodistribution and clearance mechanisms.

bioRxiv · Dec 22, 2023 · PreprintBioengineering

An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism

J. A. Lees, J. M. Dias, F. Rajamohan, J.-P. Fortin, R. O'Connor, J. X. Kong, E. Hughes, E. L. Fisher, J. B. Tuttle, G. Lovett, B. L. Kormos, R. J. Unwalla, L. Zhang, A.-M. Dechert Schmidt, D. Zhou, , S. Han

The paper reports the first structural characterization of GPR61 and identifies a potent inverse agonist, revealing an allosteric mechanism.

bioRxiv · May 1, 2023 · PreprintBiophysics

A small-molecule oral agonist of the human glucagon-like peptide-1 receptor

D. A. Griffith, D. J. Edmonds, J.-P. Fortin, A. S. Kalgutkar, J. B. Kuzmiski, P. M. Loria, A. R. Saxena, S. W. Bagley, C. Buckeridge, J. M. Curto, D. R. Derksen, J. M. Dias, M. C. Griffor, S. Han, V. M. Jackson, , D. A. Tess

The paper describes an orally bioavailable small molecule agonist of the GLP-1R that lowers blood glucose in humans.

bioRxiv · Sep 29, 2020Pharmacology & Toxicology