Author

J.-P. Fortin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

J. M. Dias· 2 shared S. Han· 2 shared A. H. Varghese· 1 shared A. Lun· 1 shared A. M. Mathiowetz· 1 shared A. Mancini· 1 shared A. Maxwell· 1 shared A. Murthy· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

J. M. Dias

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification

S. M. Haag, S. Xie, C. Eidenschenk, J.-P. Fortin, M. Callow, M. Costa, A. Lun, C. Cox, S. Z. Wu, R. N. Pradhan, J. Lock, J. A. Kuhn, L. Holokai, M. Thai, E. Freund, , A. Murthy

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

bioRxiv · Apr 12, 2024 · PreprintImmunology

An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism

J. A. Lees, J. M. Dias, F. Rajamohan, J.-P. Fortin, R. O'Connor, J. X. Kong, E. Hughes, E. L. Fisher, J. B. Tuttle, G. Lovett, B. L. Kormos, R. J. Unwalla, L. Zhang, A.-M. Dechert Schmidt, D. Zhou, , S. Han

The paper reports the first structural characterization of GPR61 and identifies a potent inverse agonist, revealing an allosteric mechanism.

bioRxiv · May 1, 2023 · PreprintBiophysics

A small-molecule oral agonist of the human glucagon-like peptide-1 receptor

D. A. Griffith, D. J. Edmonds, J.-P. Fortin, A. S. Kalgutkar, J. B. Kuzmiski, P. M. Loria, A. R. Saxena, S. W. Bagley, C. Buckeridge, J. M. Curto, D. R. Derksen, J. M. Dias, M. C. Griffor, S. Han, V. M. Jackson, , D. A. Tess

The paper describes an orally bioavailable small molecule agonist of the GLP-1R that lowers blood glucose in humans.

bioRxiv · Sep 29, 2020Pharmacology & Toxicology

Effector membrane translocation biosensors reveal G protein and β-arrestin coupling profiles of 100 therapeutically relevant GPCRs

C. Avet, A. Mancini, B. Breton, C. Le Gouill, A. S. Hauser, C. Normand, H. Kobayashi, F. Gross, M. Hogue, V. Lukasheva, S. St-Onge, M. Carrier, M. Heroux, S. Morissette, E. Fauman, , M. Bouvier

The paper develops EMTA biosensors to profile G protein and β-arrestin coupling of 100 GPCRs, revealing diverse signaling profiles and drug-target interactions.

bioRxiv · Apr 20, 2020Pharmacology & Toxicology