Author

R. J. Willems

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:variant calling· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

W. van Schaik· 3 shared A. Andremont· 1 shared A. C. Schurch· 1 shared A. Sanchez-Valenzuela· 1 shared B. Gonzalez-Zorn· 1 shared C. Payre· 1 shared D. Ehrlich· 1 shared E. Ruppe· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

W. van Schaik

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4 papers

Recent·Most cited

CRISPR-Cas9 mediated genome editing in vancomycin resistant Enterococcus faecium

V. de Maat, P. B. Stege, M. Dedden, M. Hamer, J.-P. van Pijkeren, R. J. Willems, W. van Schaik

This paper describes a CRISPR-Cas9 method to efficiently generate targeted mutants in E. faecium, reducing the time from 4-5 weeks to 3 weeks.

FEMS Microbiology Letters · Jan 6, 2020Peer-reviewedMicrobiology

Group IIA secreted phospholipase A2 in human serum kills commensal but not clinical Enterococcus faecium isolates

F. L. Paganelli, H. L. Leavis, S. He, N. M. van Sorge, C. Payre, G. Lambeau, R. J. Willems, S. H. Rooijakkers

The paper shows human serum kills commensal Enterococcus faecium but not clinical isolates, mediated by hGIIA, highlighting a potential mechanism for hGIIA resistance in clinical strains.

bioRxiv · Feb 28, 2018Microbiology

On the (im)possibility to reconstruct plasmids from whole genome short-read sequencing data

S. Arredondo-Alonso, W. van Schaik, R. J. Willems, A. C. Schurch

This study evaluates plasmid reconstruction algorithms from short-read sequencing data using reference genomes, finding that none fully and unambiguously predict plasmid sequences, with performance varying by plasmid size and assembly quality.

bioRxiv · Mar 28, 2017Microbiology

In-Depth Resistome Analysis by Targeted Metagenomics

V. F. Lanza, F. Baquero, J. L. Martinez, R. Ramos-Ruiz, B. Gonzalez-Zorn, A. Andremont, A. Sanchez-Valenzuela, D. Ehrlich, S. Kennedy, E. Ruppe, W. van Schaik, R. J. Willems, F. de la Cruz, T. M. Coque

The paper introduces ResCap, a targeted metagenomics platform for analyzing resistomes, enhancing sensitivity and specificity in detecting antimicrobial resistance genes.

bioRxiv · Jan 30, 2017Microbiology