Author

T. M. Coque

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Assay:whole-genome sequencing· 5 Organism:E. coli· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:variant calling· 2

Frequent Co-Authors

F. Baquero· 5 shared A. R. Freitas· 4 shared C. Novais· 4 shared L. Peixe· 4 shared V. F. Lanza· 4 shared A. P. Pereira· 2 shared H. Hasman· 2 shared J. Corander· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersMicrobiology

F. Baquero

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Author profile →

8 papers

Recent·Most cited

Long-term dynamics of the 'Serratia marcescens complex' in the hospital-built environment

S. Aracil-Gisbert, M. D. Fernandez-de-Bobadilla, N. Guerra-Pinto, S. Serrano-Calleja, A. E. Perez-Cobas, C. Soriano, R. De Pablo, V. F. Lanza, B. Perez-Viso, S. Reuter, H. Hasman, R. Canton, F. Baquero, T. M. Coque

The paper investigates the long-term dynamics of Serratia marcescens complex in hospital sinks, identifying persistent strains linked to outbreaks and revealing new insights into their ecology and resistance gene acquisition.

bioRxiv · Oct 15, 2023 · PreprintMicrobiology

The population-level impact of Enterococcus faecalis genetics on intestinal colonisation and extraintestinal infection

C. Chaguza, A. K. Pöntinen, J. Top, S. Arredondo-Alonso, A. R. Freitas, C. Novais, C. Torres, S. D. Bentley, L. Peixe, T. M. Coque, R. J. L. Willems, J. Corander

This study investigates the genetic factors influencing E. faecalis intestinal colonization and extraintestinal infection using GWAS and heritability analysis across 750 isolates.

bioRxiv · Sep 26, 2022 · PreprintMicrobiology

Evolution of chlorhexidine susceptibility and of the EfrEF operon among Enterococcus faecalis from diverse environments, clones and time spans

A. P. Pereira, P. Antunes, R. J. L. Willems, J. Corander, T. M. Coque, L. Peixe, A. R. Freitas, C. Novais

This study examines CHX susceptibility and ChlR-EfrEF variability in E. faecalis isolates from diverse environments, finding increased tolerance in food chain and recent human isolates.

bioRxiv · Jan 27, 2022Microbiology

Fitness cost of vancomycin-resistant Enterococcus faecium plasmids associated with hospital infection outbreaks

A. P. Tedim, V. F. Lanza, C. M. Rodriguez, A. R. Freitas, C. Novais, L. Peixe, F. Baquero, T. M. COQUE

The paper analyzes the fitness cost and stability of vancomycin-resistant plasmids in Enterococcus faecium and E. faecalis, showing reduced host fitness and plasmid stability under selective pressure.

bioRxiv · Jan 27, 2021Microbiology

A 21-year survey of Escherichia coli from bloodstream infections (BSIs) in a tertiary hospital reveals how community-hospital dynamics of the B2 phylogroup clones influence local BSI rates

I. Rodriguez, A. S. Figueiredo, M. Sousa, V. F. Lanza, C. Rodriguez, P. Mingo, J. Zamora, E. Loza, C. J. Brooks, R. Canton, F. Baquero, T. M. Coque, S. Aracil-Gisbert, M. D. Fernandez de Bobadilla

This study analyzes 21 years of E. coli bloodstream infections in a hospital, showing how community and hospital dynamics of B2 phylogroup clones influence BSI rates.

bioRxiv · Apr 10, 2020Microbiology

Simulating the Influence of Conjugative Plasmids Kinetic Values on the Multilevel Dynamics of Antimicrobial Resistance in a Membrane Computing Model

M. Campos, A. San-Milan, J.-M. Sempere, V. Fernandez-Lanza, T. M. Coque, C. Llorens, F. Baquero

This paper simulates how plasmid kinetic values affect antimicrobial resistance dynamics in a membrane computing model, finding that conjugation rates and plasmid loss rates influence plasmid dominance and resistance gene spread.

bioRxiv · Mar 27, 2020Microbiology

Identification of 2CS-CHXT operon signature of chlorhexidine tolerance among Enterococcus faecium

B. Duarte, A. P. Pereira, A. R. Freitas, T. M. Coque, A. M. Hammerum, H. Hasman, P. Antunes, L. Peixe, C. Novais

This study identifies a 2CS-CHXT operon signature associated with chlorhexidine tolerance in Enterococcus faecium and proposes an epidemiological cut-off for detection.

bioRxiv · Jul 17, 2019Microbiology

In-Depth Resistome Analysis by Targeted Metagenomics

V. F. Lanza, F. Baquero, J. L. Martinez, R. Ramos-Ruiz, B. Gonzalez-Zorn, A. Andremont, A. Sanchez-Valenzuela, D. Ehrlich, S. Kennedy, E. Ruppe, W. van Schaik, R. J. Willems, F. de la Cruz, T. M. Coque

The paper introduces ResCap, a targeted metagenomics platform for analyzing resistomes, enhancing sensitivity and specificity in detecting antimicrobial resistance genes.

bioRxiv · Jan 30, 2017Microbiology