Author

R. K. Prinjha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Coffin· 1 shared A. Gerber· 1 shared A. P. Cribbs· 1 shared A. Patel· 1 shared A. Shillings· 1 shared A. Tarakhovsky· 1 shared A. Y. F. Li Yim· 1 shared B. A. Garcia· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperImmunology

A. Coffin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation

V. Shah, G. Giotopoulos, H. Osaki, M. Meyerhoefer, E. Meduri, B. Schubert, H. Yun, S. J. Horton, S. Agrawal-Singh, P. S. Haehnel, F. Basheer, D. Lugo, M. W. Kuehn, B. Guezguez, M. Theobald, , D. Sasca

This study identifies p300-mediated compensatory transcriptional programs that drive acute resistance to BET inhibitors in AML and suggests sequential BET- and p300-inhibition as a therapeutic strategy.

bioRxiv · Sep 14, 2022 · PreprintCancer Biology

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

M. Ghiboub, J. Koster, P. D. Craggs, A. Y. F. Li Yim, A. Shillings, S. Hutchinson, R. P. Bingham, K. Gatfield, I. L. Hageman, G. Yao, H. P. O'Keefe, A. Coffin, A. Patel, L. A. Sloan, D. J. Mitchell, , W. J. de Jonge

This study identifies SP140 as a druggable epigenetic reader and therapeutic target for Crohn's disease by showing that its inhibition reduces inflammatory macrophage activation and cytokine expression.

bioRxiv · Aug 10, 2020Immunology

A histone-like motif in yellow fever virus contributes to viral replication

D. Mourao, S. Chen, U. Schaefer, L. Bozzacco, L. A. Carneiro, A. Gerber, C. Adura, B. D. Dill, H. Molina, T. Carroll, M. Paul, N. V. Bhanu, B. A. Garcia, G. Joberty, I. Rioja, , A. Tarakhovsky

This study identifies a histone-like motif in the yellow fever virus capsid protein that mimics histone H4 and interferes with BRD4-mediated gene regulation, impacting viral replication.

bioRxiv · May 5, 2020 · PreprintMicrobiology

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

A. P. Cribbs, S. Terlecki-Zaniewicz, M. Philpott, J. Baardman, D. Ahern, M. Lindow, S. Obad, H. Oerum, B. Sampey, P. Mander, H. Penn, P. Wordsworth, P. Bowness, R. K. Prinjha, M. de Winther, , U. Oppermann

This study identifies KDM6A and KDM6B as regulators of human Th17 cell development and effector functions by affecting metabolism and cytokine production.

bioRxiv · Oct 30, 2019Immunology