Author

R. K. S. Malireddi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

T.-D. Kanneganti· 4 shared B. R. Sharma· 2 shared P. Vogel· 2 shared A. Brown· 1 shared A. Burton· 1 shared A. Monahan· 1 shared A. Nagar· 1 shared A. Nandy· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersImmunology

T.-D. Kanneganti

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4 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 29, 2022

Methotrexate inhibition of muropeptide transporter SLC46A2 controls psoriatic skin inflammation

R. Bharadwaj, C. F. Lusi, S. Mashayekh…·N. Silverman

The paper shows that SLC46A2 transports DAP-muropeptides to activate NOD1 in keratinocytes, and methotrexate inhibits this transport, reducing psoriatic inflammation.

DOI 10.1101/2022.09.29.509906

mouseexperimental assay

𝕏 PostBluesky

Cell BiologybioRxivSep 21, 2022

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

R. K. S. Malireddi, R. Bynigeri, B. Kancharana…·T.-D. Kanneganti

The paper generates a new IL-1α knockout mouse line (Il1a-KOline2) that maintains normal IL-1β expression, revealing IL-1's independent role in neutrophil chemoattractant production.

DOI 10.3389/fimmu.2022.1068230

mousegenetic perturbation / CRISPR

𝕏 PostBluesky

ImmunologybioRxivOct 29, 2020

Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

R. Karki, B. R. Sharma, S. Tuladhar…·T.-D. Kanneganti

DOI 10.1016/j.cell.2020.11.025

humanexperimental assay

𝕏 PostBluesky

ImmunologybioRxivApr 5, 2020

Za2 domain of ZBP1 is a molecular switch regulating Influenza-induced PANoptosis and perinatal lethality during development

S. Kesavardhana, R. K. S. Malireddi, A. Burton…·T.-D. Kanneganti

This study identifies the Z2 domain of ZBP1 as critical for influenza-induced PANoptosis and perinatal lethality in mice.

DOI 10.1074/jbc.ra120.013752

mouseexperimental assay

𝕏 PostBluesky