T.-D. Kanneganti

Methotrexate inhibition of muropeptide transporter SLC46A2 controls psoriatic skin inflammation

The paper shows that SLC46A2 transports DAP-muropeptides to activate NOD1 in keratinocytes, and methotrexate inhibits this transport, reducing psoriatic inflammation.

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

The paper generates a new IL-1α knockout mouse line (Il1a-KOline2) that maintains normal IL-1β expression, revealing IL-1's independent role in neutrophil chemoattractant production.

Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver

This study shows that limited Caspase-1 cleavage in hepatocytes reduces pyroptosis and cytokine maturation, impairing malaria control, and that enhancing ASC expression improves immune response.

Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy

This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.

Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

Za2 domain of ZBP1 is a molecular switch regulating Influenza-induced PANoptosis and perinatal lethality during development

This study identifies the Z2 domain of ZBP1 as critical for influenza-induced PANoptosis and perinatal lethality in mice.

HA stability regulates H1N1 influenza virus replication and pathogenicity in mice by modulating type I interferon responses in dendritic cells

This paper shows that a destabilizing HA mutation in H1N1 influenza virus reduces replication and pathogenicity in mice by enhancing type I interferon responses in dendritic cells.