Author

R. K. Shields

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:whole-genome sequencing· 5 Organism:human· 3 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Van Tyne· 4 shared Y. Doi· 4 shared H. R. Nordstrom· 3 shared A. Iovleva· 2 shared C. L. McElheny· 2 shared D. R. Evans· 2 shared K. J. Westbrook· 2 shared M. P. Griffith· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersMicrobiology

D. Van Tyne

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Harnessing the diversity of Burkholderia spp. prophages for therapeutic potential

H. R. Nordstrom, M. P. Griffith, V. R. Srinivasa, N. R. Wallace, A. Li, V. S. Cooper, R. K. Shields, D. Van Tyne

The paper identifies prophages in Burkholderia spp. genomes that show lytic activity against conspecific and heterospecific isolates, suggesting their potential for phage therapy.

bioRxiv · Jan 24, 2024 · PreprintMicrobiology

High-level ceftazidime-avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated beta-lactamase CMY-185 variant

W. C. Shropshire, B. T. Endres, J. Borjan, S. L. Aitken, W. C. Bachman, C. L. McElheny, A. Khan, M. M. Bhatti, P. Saharasbhojane, A. Kawai, R. K. Shields, S. A. Shelburne, Y. Doi

The paper identifies a novel CMY-185 beta-lactamase variant in E. coli that confers high-level resistance to ceftazidime-avibactam through specific amino acid substitutions.

bioRxiv · Feb 3, 2023Microbiology

Within-host genotypic and phenotypic diversity of contemporaneous carbapenem-resistant Klebsiella pneumoniae from blood cultures of patients with bacteremia

S. Cheng, G. Fleres, L. Chen, G. Liu, B. Hao, A. Newbrough, E. Driscoll, R. K. Shields, K. M. Squires, T. Chu, B. N. Kreiswirth, M. H. Nguyen, C. J. Clancy

The paper identifies genotypic and phenotypic diversity among CRKP strains from individual patients' blood cultures, showing they are genetically distinct and exhibit different antibiotic responses and virulence traits.

bioRxiv · May 26, 2022Microbiology

Genomic and functional characterization of Pseudomonas aeruginosa-targeting bacteriophages isolated from hospital wastewater

H. R. Nordstrom, D. R. Evans, A. G. Finney, K. J. Westbrook, P. F. Zamora, A. Iovleva, M. H. Yassin, J. M. Bomberger, R. K. Shields, Y. Doi, D. Van Tyne

This study isolates and characterizes 14 new Pseudomonas aeruginosa-targeting phages from hospital wastewater and evaluates their antibacterial activity against clinical isolates and biofilms.

bioRxiv · Jul 8, 2021 · PreprintMicrobiology

Differential ampicillin/ceftriaxone susceptibility among diverse Enterococcus faecalis from infective endocarditis

K. J. Westbrook, G. S. Chilambi, H. R. Nordstrom, A. Iovleva, N. H. Shah, C. E. Jones, E. G. Kline, Y. Doi, R. K. Shields, D. Van Tyne

This study examines antimicrobial susceptibility of E. faecalis isolates from infective endocarditis, finding reduced ceftriaxone activity in strains with PBP4 and IreP mutations.

bioRxiv · Jun 7, 2021 · PreprintMicrobiology

Clinical and genomic epidemiology of carbapenem-non-susceptible Citrobacter spp. at a tertiary healthcare center over two decades

A. Babiker, D. R. Evans, M. P. Griffith, C. L. McElheny, M. Hassan, L. G. Clarke, R. T. Mettus, L. H. Harrison, Y. Doi, R. K. Shields, D. Van Tyne

The paper analyzes the clinical and genomic epidemiology of carbapenem-non-susceptible Citrobacter spp. over two decades, finding increased prevalence and genetic diversity with carbapenemase-encoding plasmids.

Journal of Clinical Microbiology · Aug 24, 2020Peer-reviewedMicrobiology