Author

D. Van Tyne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 14

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Assay:whole-genome sequencing· 9 Organism:bacteria (other)· 5 Organism:human· 5 Approach:statistical model· 5 Research Focus:host-pathogen & immune response· 4 Organism:E. coli· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

M. P. Griffith· 7 shared D. R. Evans· 6 shared Y. Doi· 6 shared H. R. Nordstrom· 5 shared L. H. Harrison· 4 shared R. K. Shields· 4 shared V. S. Cooper· 4 shared A. Iovleva· 3 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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7 shared papersMicrobiology

M. P. Griffith

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Author profile →

14 papers

Recent·Most cited

Lytic bacteriophages interact with respiratory epithelial cells and induce the secretion of antiviral and proinflammatory cytokines

P. F. Zamora, T. G. Reidy, C. R. Armbruster, M. Sun, D. Van Tyne, P. E. Turner, J. L. Koff, J. M. Bomberger

This study investigates how lytic bacteriophages interact with respiratory epithelial cells and their effects on cytokine secretion, highlighting the need to consider mammalian responses in phage therapy.

bioRxiv · Feb 6, 2024 · PreprintMicrobiology

Harnessing the diversity of Burkholderia spp. prophages for therapeutic potential

H. R. Nordstrom, M. P. Griffith, V. R. Srinivasa, N. R. Wallace, A. Li, V. S. Cooper, R. K. Shields, D. Van Tyne

The paper identifies prophages in Burkholderia spp. genomes that show lytic activity against conspecific and heterospecific isolates, suggesting their potential for phage therapy.

bioRxiv · Jan 24, 2024 · PreprintMicrobiology

Evolution of extended-spectrum β-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years

S.-T. Cho, E. G. Mills, M. P. Griffith, H. R. Nordstrom, C. L. McElheny, L. H. Harrison, Y. Doi, D. Van Tyne

This study tracks the evolution of ST131 E. coli over 15 years at a single hospital, identifying dominant subclades and genetic adaptations associated with ESBL production.

bioRxiv · Dec 11, 2023 · PreprintMicrobiology

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection

W. Bain, B. Ahn, H. Penaloza, C. McElheny, N. Tolman, R. van der Geest, S. Gonzalez-Ferrer, N. Chen, X. An, R. Hosuru, M. Tabary, E. Papke, N. Kohli, N. Farooq, W. Bachman, , J. Lee

The paper identifies a capsule defect in K. pneumoniae that enhances complement-mediated opsonophagocytosis and persistence during recurrent infections.

bioRxiv · May 31, 2023 · PreprintMicrobiology

The Type VI Secretion System of the Emerging Pathogen Stenotrophomonas maltophilia has Antibacterial Properties

C. Crisan, D. Van Tyne, J. B. Goldberg

This study shows that the T6SS of S. maltophilia can eliminate other bacteria and enhance its competitive fitness against Pseudomonas aeruginosa.

bioRxiv · May 30, 2023 · PreprintMicrobiology

Global diversity of enterococci and description of 18 novel species

J. A. Schwartzman, F. Lebreton, R. Salamzade, M. J. Martin, K. Schaufler, A. Urhan, T. Abeel, I. L. B. C. Camargo, B. F. Sgardioli, J. Prichula, A. P. G. Frazzon, D. Van Tyne, G. Treinish, C. J. Innis, J. A. Wagenaar, , M. S. Gilmore

This study identifies 18 new enterococcal species from global samples, revealing host associations and genetic diversity within the genus.

bioRxiv · May 18, 2023 · PreprintMicrobiology

Targeted IS-element sequencing uncovers transposition dynamics during selective pressure in enterococci

J. M. Kirsch, S. Ely, M. E. Stellfox, K. Hullahalli, P. Luong, K. L. Palmer, D. Van Tyne, B. A. Duerkop

This study uses IS-Seq to show that phage infection and antibiotic exposure drive IS256 diversification in enterococci, linking selective pressures to genome evolution.

bioRxiv · Aug 24, 2022Microbiology

Genomic diversity of hospital-acquired infections revealed through prospective whole genome sequencing-based surveillance

M. M. Mustapha, V. R. Srinivasa, M. P. Griffith, S.-T. Cho, D. R. Evans, K. Waggle, C. Ezeonwuka, D. Snyder, J. W. Marsh, L. H. Harrison, V. S. Cooper, D. Van Tyne

This study uses whole-genome sequencing to analyze 3,004 bacterial isolates from hospitalized patients, revealing genomic diversity and evolutionary rates across 97 species and informing outbreak detection.

bioRxiv · Oct 27, 2021Microbiology

Carbapenem-Resistant Acinetobacter baumannii in US hospitals: diversification of circulating lineages and antimicrobial resistance

A. V. Iovleva, M. M. Mustapha, M. P. Griffith, L. Komarow, C. Luterbach, D. R. Evans, E. Cober, S. S. Richter, K. Rydell, C. A. Arias, J. T. Jacob, R. A. Salata, M. J. Satlin, D. Wong, R. A. Bonomo, , Y. Doi

This study analyzes CRAb isolates from US hospitals using WGS, identifying new sub-lineages and resistance patterns, highlighting shifts in CRAb population structure and clinical impact.

bioRxiv · Sep 21, 2021 · PreprintMicrobiology

Genomic and functional characterization of Pseudomonas aeruginosa-targeting bacteriophages isolated from hospital wastewater

H. R. Nordstrom, D. R. Evans, A. G. Finney, K. J. Westbrook, P. F. Zamora, A. Iovleva, M. H. Yassin, J. M. Bomberger, R. K. Shields, Y. Doi, D. Van Tyne

This study isolates and characterizes 14 new Pseudomonas aeruginosa-targeting phages from hospital wastewater and evaluates their antibacterial activity against clinical isolates and biofilms.

bioRxiv · Jul 8, 2021 · PreprintMicrobiology

Differential ampicillin/ceftriaxone susceptibility among diverse Enterococcus faecalis from infective endocarditis

K. J. Westbrook, G. S. Chilambi, H. R. Nordstrom, A. Iovleva, N. H. Shah, C. E. Jones, E. G. Kline, Y. Doi, R. K. Shields, D. Van Tyne

This study examines antimicrobial susceptibility of E. faecalis isolates from infective endocarditis, finding reduced ceftriaxone activity in strains with PBP4 and IreP mutations.

bioRxiv · Jun 7, 2021 · PreprintMicrobiology

Clinical and genomic epidemiology of carbapenem-non-susceptible Citrobacter spp. at a tertiary healthcare center over two decades

A. Babiker, D. R. Evans, M. P. Griffith, C. L. McElheny, M. Hassan, L. G. Clarke, R. T. Mettus, L. H. Harrison, Y. Doi, R. K. Shields, D. Van Tyne

The paper analyzes the clinical and genomic epidemiology of carbapenem-non-susceptible Citrobacter spp. over two decades, finding increased prevalence and genetic diversity with carbapenemase-encoding plasmids.

Journal of Clinical Microbiology · Aug 24, 2020Peer-reviewedMicrobiology

Genomic and phenotypic diversity of Enterococcus faecalis isolated from endophthalmitis

G. S. Chilambi, H. R. Nordstrom, D. R. Evans, R. P. Kowalski, D. K. Dhaliwal, V. Jhanji, R. M. Shanks, D. Van Tyne

This study examines genomic and phenotypic diversity of Enterococcus faecalis isolates from endophthalmitis patients, revealing genetic and phenotypic variability and evidence of adaptive mutations during recurrent infection.

bioRxiv · Aug 5, 2020Microbiology

Comprehensive analysis of horizontal gene transfer among multidrug-resistant bacterial pathogens in a single hospital

D. R. Evans, M. P. Griffith, M. M. Mustapha, J. W. Marsh, A. J. Sundermann, V. S. Cooper, L. H. Harrison, D. Van Tyne

This study tracks horizontal gene transfer of mobile genetic elements in a hospital setting using genomic analysis of 2,173 bacterial isolates.

eLife · Apr 14, 2020Peer-reviewedMicrobiology