Author

R. L. Fischer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Plant Biology· 4

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Organism:Arabidopsis· 4 Research Focus:chromatin & epigenetic regulation· 4 Assay:DNA methylation· 4 Approach:experimental assay· 3 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

J. M. Frost· 3 shared P.-H. Hsieh· 3 shared T.-F. Hsieh· 3 shared Y. Choi· 3 shared D. Zilberman· 2 shared A. Runkel· 1 shared C. Zhang· 1 shared D. Zhang· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersPlant Biology

J. M. Frost

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4 papers

Recent·Most cited

Embryo-specific epigenetic mechanisms reconstitute the CHH methylation landscape during Arabidopsis embryogenesis

P.-H. Hsieh, J. M. Frost, Y. Choi, T.-F. Hsieh, D. Zilberman, R. L. Fischer

This study identifies embryo-specific epigenetic mechanisms that reprogram CHH methylation during Arabidopsis embryogenesis, revealing distinct roles for RdDM and CMT2 pathways.

bioRxiv · Apr 6, 2023 · PreprintPlant Biology

H2A.X mutants exhibit enhanced DNA demethylation in Arabidopsis thaliana

J. M. Frost, J. Lee, P.-H. Hsieh, S. J. Lin, Y. Min, M. Bauer, A. Runkel, H.-T. Cho, T.-F. Hsieh, Y. Choi, R. L. Fischer

This study shows that H2A.X mutants in Arabidopsis thaliana exhibit reduced CG DNA methylation in endosperm, primarily in transposons and intergenic regions, suggesting H2A.X's role in maintaining methylation homeostasis.

bioRxiv · Jan 8, 2023 · PreprintPlant Biology

The Catalytic Core of DEMETER Guides Active DNA Demethylation in Arabidopsis

C. Zhang, Y.-H. Hung, X.-Q. Zhang, D. Zhang, J. M. Frost, F. Liu, W. Xiao, L. M. Iyer, L. Aravind, J. H. Huh, R. L. Fischer, T.-F. Hsieh

This study identifies the catalytic core of DME as essential for active DNA demethylation in Arabidopsis, showing that the N-terminus is required for heterochromatin demethylation and specificity.

bioRxiv · May 1, 2019Plant Biology

The FACT complex is required for DNA demethylation at heterochromatin during reproduction in Arabidopsis

J. Frost, M. Y. Kim, G.-T. Park, P.-H. Hsieh, M. Nakamura, S. Lin, H. Yoo, J. Choi, Y. Ikeda, T. Kinoshita, Y. Choi, D. Zilberman, R. L. Fischer

This study shows that the FACT complex facilitates DME-mediated DNA demethylation at heterochromatin during Arabidopsis reproduction by enabling access to GC-rich, nucleosome-dense regions.

bioRxiv · Sep 12, 2017Plant Biology