Author

J. M. Frost

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Plant Biology· 3 Physiology· 1

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Organism:Arabidopsis· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:DNA methylation· 3 Approach:experimental assay· 3 Approach:comparative / phylogenetic analysis· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

R. L. Fischer· 3 shared T.-F. Hsieh· 3 shared P.-H. Hsieh· 2 shared Y. Choi· 2 shared A. Manousopoulou· 1 shared A. Runkel· 1 shared B. Ashley· 1 shared C. Cooper· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersPlant Biology

R. L. Fischer

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Author profile →

4 papers

Recent·Most cited

Embryo-specific epigenetic mechanisms reconstitute the CHH methylation landscape during Arabidopsis embryogenesis

P.-H. Hsieh, J. M. Frost, Y. Choi, T.-F. Hsieh, D. Zilberman, R. L. Fischer

This study identifies embryo-specific epigenetic mechanisms that reprogram CHH methylation during Arabidopsis embryogenesis, revealing distinct roles for RdDM and CMT2 pathways.

bioRxiv · Apr 6, 2023 · PreprintPlant Biology

H2A.X mutants exhibit enhanced DNA demethylation in Arabidopsis thaliana

J. M. Frost, J. Lee, P.-H. Hsieh, S. J. Lin, Y. Min, M. Bauer, A. Runkel, H.-T. Cho, T.-F. Hsieh, Y. Choi, R. L. Fischer

This study shows that H2A.X mutants in Arabidopsis thaliana exhibit reduced CG DNA methylation in endosperm, primarily in transposons and intergenic regions, suggesting H2A.X's role in maintaining methylation homeostasis.

bioRxiv · Jan 8, 2023 · PreprintPlant Biology

Placental uptake and metabolism of 25(OH)Vitamin D determines its activity within the fetoplacental unit

B. Ashley, C. Simner, A. Manousopoulou, C. Jenkinson, F. Hey, J. M. Frost, F. I. Rezwan, C. H. White, E. M. Lofthouse, E. Hyde, L. Cooke, S. Barton, P. Mahon, E. M. Curtis, R. J. Moon, , J. K. Cleal

This study shows the human placenta actively transports and metabolizes 25(OH)D3 into active vitamin D metabolites, influencing fetal development through placental transcriptome and proteome changes.

eLife · Mar 8, 2022Peer-reviewedPhysiology

The Catalytic Core of DEMETER Guides Active DNA Demethylation in Arabidopsis

C. Zhang, Y.-H. Hung, X.-Q. Zhang, D. Zhang, J. M. Frost, F. Liu, W. Xiao, L. M. Iyer, L. Aravind, J. H. Huh, R. L. Fischer, T.-F. Hsieh

This study identifies the catalytic core of DME as essential for active DNA demethylation in Arabidopsis, showing that the N-terminus is required for heterochromatin demethylation and specificity.

bioRxiv · May 1, 2019Plant Biology