Author

A. Haldane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 5 Organism:human· 3 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Assay:proteomics· 2 Approach:simulation· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Biswas· 3 shared R. Levy· 3 shared A. Thakur· 2 shared D. Lyumkis· 2 shared I. Choudhuri· 2 shared J. Gizzio· 2 shared R. M. Levy· 2 shared B. S. Magenheimer· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

A. Biswas

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Evolutionary sequence and structural basis for the distinct conformational landscapes of Tyr and Ser/Thr kinases

J. Gizzio, A. Thakur, A. Haldane, C. B. Post, R. Levy

The paper investigates the structural basis for the distinct conformational landscapes of tyrosine and serine/threonine kinases using sequence and structure-based models.

bioRxiv · Mar 8, 2024 · PreprintBiophysics

Activation of Polycystin-1 Signaling by Binding of Stalk-derived Peptide Agonists

S. Pawnikar, B. S. Magenheimer, K. Joshi, E. Nevarez-Munoz, A. Haldane, R. L. Maser, Y. Miao

This study identifies stalk-derived peptides that activate PC1 signaling by binding to specific regions, revealing structural dynamics and potential therapeutic applications for ADPKD.

bioRxiv · Jan 6, 2024Biochemistry

Mechanisms of HIV-1 Integrase Resistance to Dolutegravir and Potent Inhibition of Drug Resistant Variants

M. Li, D. Passos, Z. Shan, S. J. Smith, Q. Sun, A. Biswas, I. Choudhuri, T. Strutzenberg, A. Haldane, N. Deng, Z. Li, X.-Z. Zhao, T. R. Burke, R. M. Levy, S. H. Hughes, , D. Lyumkis

The paper investigates mechanisms of HIV-1 integrase resistance to Dolutegravir and shows that 4d is more effective against resistant variants.

bioRxiv · Dec 4, 2022Biophysics

Kinetic co-evolutionary models predict the temporal emergence of HIV resistance mutations under drug selection pressure

A. Biswas, I. Choudhuri, E. Arnold, D. Lyumkis, A. Haldane, R. Levy

This paper uses kinetic co-evolutionary models to predict the temporal emergence of HIV resistance mutations under drug selection pressure, showing that epistasis determines DRM acquisition rates.

bioRxiv · Nov 30, 2022 · PreprintBiophysics

Evolutionary Divergence in the Conformational Landscapes of Tyrosine vs Serine/Threonine Kinases

J. Gizzio, A. Thakur, A. Haldane, R. M. Levy

The paper investigates conformational differences between tyrosine and serine/threonine kinases using sequence analysis and simulations to explain binding affinity differences for type-II inhibitors.

bioRxiv · Aug 29, 2022Biophysics

The role of epistasis in determining the fitness landscape of HIV proteins

A. Biswas, A. Haldane, R. Levy

This paper investigates epistasis in HIV proteins, showing strong evidence for long-range epistasis through sequence models but weak evidence from experimental fitness measures.

bioRxiv · Jun 16, 2021Biophysics