Author

S. Pawnikar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 4 Approach:statistical model· 4 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Y. Miao· 4 shared B. S. Magenheimer· 2 shared E. Nevarez-Munoz· 2 shared R. L. Maser· 2 shared A. Bhattarai· 1 shared A. Haldane· 1 shared E. Mantei· 1 shared J. Wang· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiochemistry

Y. Miao

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4 papers

Recent·Most cited

Activation of Polycystin-1 Signaling by Binding of Stalk-derived Peptide Agonists

S. Pawnikar, B. S. Magenheimer, K. Joshi, E. Nevarez-Munoz, A. Haldane, R. L. Maser, Y. Miao

This study identifies stalk-derived peptides that activate PC1 signaling by binding to specific regions, revealing structural dynamics and potential therapeutic applications for ADPKD.

bioRxiv · Jan 6, 2024Biochemistry

Mechanistic insights into ligand dissociation from the SARS-CoV-2 spike glycoprotein

T. A. Hasse, E. Mantei, R. Shahoei, S. Pawnikar, J. Wang, Y. Miao, Y.-m. M. Huang

This study investigates ligand dissociation from the SARS-CoV-2 spike glycoprotein using simulations, revealing two unbinding pathways and key residues involved in ligand binding and ACE2 interaction.

bioRxiv · Nov 29, 2023Biophysics

Mechanism of Tethered Agonist-Mediated Signaling by Polycystin-1

S. Pawnikar, B. S. Magenheimer, E. Nevarez-Munoz, R. L. Maser, Y. Miao

This paper investigates the mechanism of tethered agonist-mediated signaling in PC1 CTF using simulations and experiments, revealing an allosteric pathway involving specific residue interactions.

bioRxiv · Aug 5, 2021Biochemistry

Mechanism of ligand recognition by human ACE2 receptor

A. Bhattarai, S. Pawnikar, Y. Miao

This study uses LiGaMD simulations to reveal conformational changes in human ACE2 upon ligand binding, suggesting a conformational selection mechanism for ligand recognition.

bioRxiv · Oct 30, 2020Biophysics