Author

R. La Rosa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

H. K. Johansen· 5 shared S. Molin· 5 shared I. Pogrebnyakov· 2 shared L. Goltermann· 2 shared A. Espaillat· 1 shared A. Jimenez· 1 shared B. H. Pedersen· 1 shared C. A. Colque· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersMicrobiology

H. K. Johansen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa

L. Goltermann, P. Laborda, O. Irazoqui, I. Pogrebnyakov, S. Molin, H. K. Johansen, R. La Rosa

This study shows that macrolides are effective against Pseudomonas aeruginosa in airway infections but lead to resistance via uL4 and uL22 ribosomal mutations, requiring higher antibiotic concentrations and reducing bacterial fitness.

bioRxiv · Apr 11, 2024 · PreprintMicrobiology

Adaptive evolution of P. aeruginosa in human airways shows phenotypic convergence despite diverse patterns of genomic changes

A. Espaillat, C. A. Colque, D. Rago, R. La Rosa, S. Molin, H. K. Johansen

This study tracks Pseudomonas aeruginosa evolution in 9 cystic fibrosis patients over decades, finding phenotypic convergence despite genomic divergence and reduced virulence features.

bioRxiv · Jul 19, 2023 · PreprintMicrobiology

Detuning of the Ribosome Conformational Landscape Promotes Antibiotic Resistance and Collateral Sensitivity

P. Mesa, R. La Rosa, A. Jimenez, R. Espinosa-Portero, H. K. Johansen, S. Molin, G. Montoya

The paper identifies a ribosome mutation that causes antibiotic resistance by altering conformational dynamics and reveals new tobramycin binding sites, leading to collateral sensitivity to chloramphenicol.

bioRxiv · Jun 13, 2023 · PreprintBiophysics

Metabolic specialization drives reduced pathogenicity in Pseudomonas aeruginosa CF clinical isolates

B. H. Pedersen, F. Simoes, I. Pogrebnyakov, M. Welch, H. K. Johansen, S. Molin, R. La Rosa

This study shows that metabolic adaptations in Pseudomonas aeruginosa clinical isolates reduce pathogenicity and virulence in cystic fibrosis patients.

bioRxiv · Apr 17, 2023 · PreprintMicrobiology

Macrolide therapy in Pseudomonas aeruginosa infections causes uL4 ribosomal protein mutations leading to high-level resistance

L. Goltermann, K. L. Andersen, H. K. Johansen, S. Molin, R. La Rosa

bioRxiv · Feb 28, 2022Microbiology