Author

R. Ledesma-Amaro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 4 Research Focus:drug response / drug discovery· 3 Assay:metabolomics· 2 Organism:Arabidopsis· 1 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

H. Peng· 2 shared A. Serrano-Mislata· 1 shared C. Mürk· 1 shared C. Urbez· 1 shared D. Kang· 1 shared E. Moldenhauer· 1 shared G. Bhutada· 1 shared G. Menard· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersMicrobiology

H. Peng

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Bioconversion of Glucose-Rich Lignocellulosic Wood Hydrolysates to 3-Hydroxypropionic Acid and Succinic Acid using Engineered Saccharomyces cerevisiae

S. Bottoms, C. Mürk, H. Peng, R. Ledesma-Amaro, M. Loog

This study engineers Saccharomyces cerevisiae to produce 3-hydroxypropionic acid and succinic acid from glucose-rich lignocellulosic wood hydrolysates under low pH conditions, increasing production titers significantly.

bioRxiv · Nov 23, 2023 · PreprintMicrobiology

DELLA Proteins Recruit the Mediator Complex Subunit MED15 to Co-activate Transcription in Land Plants

J. Hernandez-Garcia, A. Serrano-Mislata, M. Lozano-Quiles, C. Urbez, M. A. Nohales, N. Blanco-Tourinan, H. Peng, R. Ledesma-Amaro, M. A. Blazquez

This paper identifies DELLA proteins as co-activators that recruit the Mediator subunit MED15 to facilitate transcription in land plants, showing conservation from Arabidopsis to liverworts.

bioRxiv · Nov 1, 2023Plant Biology

A yeast-based tool for mammalian DGATs inhibitors screening

P. Gajdos, R. Ledesma-Amaro, J.-M. Nicaud, t. Rossignol

This paper demonstrates a yeast-based system for screening inhibitors of mammalian DGAT2 enzymes, showing its utility in identifying potential therapeutic compounds.

bioRxiv · Jul 6, 2022Microbiology

Production of human milk fat substitute by engineered strains of Yarrowia lipolytica

G. Bhutada, G. Menard, R. Ledesma-Amaro, P. J. Eastmond

This paper engineers Yarrowia lipolytica to produce triacylglycerol with over 60% palmitic acid in the sn-2 position, mimicking human milk fat for infant formula use.

bioRxiv · Jul 30, 2021Bioengineering

Comparative genomics analysis of Chryseobacterium sp. KMC2 reveals metabolic pathways involved in keratinous utilization and natural product biosynthesis

D. Kang, S. Shoaie, S. Jacquiod, S. J. Sorensen, R. Ledesma-Amaro

This study uses comparative genomics to analyze Chryseobacterium sp. KMC2 and identifies secondary metabolite gene clusters and metabolic pathways involved in keratin utilization and natural product biosynthesis.

bioRxiv · Feb 23, 2021 · PreprintMicrobiology

Drop-In Biofuel production by using fatty acid photodecarboxylase from Chlorella variabilis in the oleaginous yeast Yarrowia lipolytica.

S. Bruder, E. Moldenhauer, R. Ledesma-Amaro, J. Kabisch

The paper demonstrates the production of odd-chain alkanes and alkenes in Yarrowia lipolytica using fatty acid photodecarboxylase from Chlorella variabilis, achieving hydrocarbon titers up to 58.7 mg/L.

bioRxiv · Apr 27, 2019Bioengineering