Author

S. Bottoms

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Higbee· 2 shared D. Xie· 2 shared J. J. Coon· 2 shared J. S. Piotrowski· 2 shared J. Serate· 2 shared M. Loog· 2 shared Q. Dickinson· 2 shared Y. Zhang· 2 shared

Activity by Year

2016-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBioengineering

A. Higbee

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Bioconversion of Glucose-Rich Lignocellulosic Wood Hydrolysates to 3-Hydroxypropionic Acid and Succinic Acid using Engineered Saccharomyces cerevisiae

S. Bottoms, C. Mürk, H. Peng, R. Ledesma-Amaro, M. Loog

This study engineers Saccharomyces cerevisiae to produce 3-hydroxypropionic acid and succinic acid from glucose-rich lignocellulosic wood hydrolysates under low pH conditions, increasing production titers significantly.

bioRxiv · Nov 23, 2023 · PreprintMicrobiology

Conversion of aromatic compounds from fractionated industrial hydrolysis lignin by Pseudomonas putida and environmental strains

P. A. Morehead, H. Vider, C. Murk, S. Viggor, M. Joesaar, S. Bottoms, S. Salmar, M. Kivisaar, M. Loog

This study evaluates the use of fractionated hydrolysis lignin as a substrate for Pseudomonas putida and related strains to produce aromatic compounds, finding that filtered alkaline fractionation yields more catechol and is better for cis,cis-muconic acid production.

bioRxiv · Oct 19, 2023 · PreprintMicrobiology

Chemical genomic guided engineering of gamma-valerolactone tolerant yeast

S. Bottoms, Q. Dickinson, M. McGee, L. Hinchman, A. Higbee, A. Hebert, J. Serate, D. Xie, Y. Zhang, J. J. Coon, C. L. Myers, R. Landick, J. S. Piotrowski

The paper engineers a GVL-tolerant yeast strain by deleting PAD1 and FDC1, enhancing ergosterol content and improving fermentation in GVL-containing hydrolysates.

bioRxiv · Nov 4, 2017Bioengineering

Inhibition of microbial biofuel production in drought stressed switchgrass hydrolysate

R. G. Ong, A. Higbee, S. Bottoms, Q. Dickinson, D. Xie, S. A. Smith, J. Serate, E. Pohlmann, A. D. Jones, J. J. Coon, T. K. Sato, G. R. Sanford, D. Eilert, L. G. Oates, J. S. Piotrowski, , Y. Zhang

This study investigates how drought stress in switchgrass affects biofuel production by inhibiting yeast fermentation due to the formation of toxic compounds during pretreatment.

bioRxiv · Oct 26, 2016Microbiology