R. M. Rodriguiz

This study shows that lisuride, a G protein biased 5-HT2AR agonist, produces anti-depressant effects in mice without hallucinogenic actions, with limited involvement of β-arrestin pathways.

This paper develops ML321, a highly selective D2 dopamine receptor antagonist, showing efficacy in animal models predictive of atypical antipsychotic activity with fewer side effects.

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

The paper shows that GIT2 deficiency does not impair learning and memory due to a brain-specific splice variant that avoids forming GIT/PIX complexes.