W. C. Wetsel

Presynaptic Rac1 in the hippocampus selectively regulates working memory

This study shows that presynaptic Rac1 signaling selectively regulates spatial working memory, with distinct effects on synaptic vesicles and morphology compared to postsynaptic Rac1 inhibition.

The G protein biased serotonin 5-HT 2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice

This study shows that lisuride, a G protein biased 5-HT2AR agonist, produces anti-depressant effects in mice without hallucinogenic actions, with limited involvement of β-arrestin pathways.

Identification and Characterization of ML321: a Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models that Predict Atypical Antipsychotic Activity

This paper develops ML321, a highly selective D2 dopamine receptor antagonist, showing efficacy in animal models predictive of atypical antipsychotic activity with fewer side effects.

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

GIT2 is dispensable for normal learning and memory function due to a predominant brain GIT2 splice variant that evades GIT/PIX complexes.

The paper shows that GIT2 deficiency does not impair learning and memory due to a brain-specific splice variant that avoids forming GIT/PIX complexes.