4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis
T. Levy, K. Voeltzke, L. Hauffe, K. Alasad, M. Snaebjornsson, R. Marciano, K. Scharov, M. Planque, K. Vriens, S. Christen, C. M. Funk, C. Hassiepen, A. Kahler, B. Heider, D. Picard, , G. Leprivier
This study shows 4EBP1/2 promote cell survival under glucose starvation by repressing fatty acid synthesis and maintaining redox balance, supporting tumorigenicity in cancer cells.
bioRxiv · Sep 9, 2022 · PreprintCell Biology