Author

C. M. Funk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Banito· 3 shared F. Cidre-Aranaz· 3 shared J. Li· 3 shared R. Imle· 3 shared S. Ohmura· 3 shared T. G. P. Gruenewald· 3 shared A. K. Ceranski· 2 shared E. Vinca· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Banito

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma

E. Vinca, A. C. Ehlers, A. Ritter, D. Obermeier, C. M. Funk, F. H. Geyer, M. Schmucker, J. Li, M. Zimmermann, A. K. Ceranski, F. Fuchslocher, C. Mertens, R. Qiu, M. M. Muckenthaler, A. Dahlhaus, , S. Ohmura

This study identifies GLRX3 as a vulnerability in Ewing sarcoma driven by EWSR1::FLI1 fusion oncoproteins, showing its role in oxidative stress and iron homeostasis and potential therapeutic targeting.

bioRxiv · Apr 24, 2024 · PreprintCancer Biology

Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition

C. M. Funk, A. Ehlers, M. F. Orth, K. Aljakouch, J. Li, T. L. B. Hoelting, R. Will, A. K. Ceranski, F. Willis, E. Vinca, S. Ohmura, R. Imle, J. Siebenlist, A. Yershova, M. M. L. Knott, , J. Musa

This study identifies chr8 gains and 4E-BP1 expression as prognostic markers in Ewing sarcoma, showing they drive cancer progression by promoting proliferation and sensitizing to CDK4/6 inhibitors.

bioRxiv · Dec 11, 2022 · PreprintCancer Biology

4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis

T. Levy, K. Voeltzke, L. Hauffe, K. Alasad, M. Snaebjornsson, R. Marciano, K. Scharov, M. Planque, K. Vriens, S. Christen, C. M. Funk, C. Hassiepen, A. Kahler, B. Heider, D. Picard, , G. Leprivier

This study shows 4EBP1/2 promote cell survival under glucose starvation by repressing fatty acid synthesis and maintaining redox balance, supporting tumorigenicity in cancer cells.

bioRxiv · Sep 9, 2022 · PreprintCell Biology

Systems biology analysis identifies TCF7L1 as a key regulator of metastasis in Ewing sarcoma

F. Cidre-Aranaz, J. Li, T. L. B. Hoelting, M. F. Orth, R. Imle, S. Kutschmann, G. Ammirati, K. Ceranski, M. J. Carreno-Gonzalez, M. Kasan, A. Marchetto, C. M. Funk, F. Bestvater, S. Bersini, C. Arrigoni, , T. G. P. Gruenewald

bioRxiv · Feb 25, 2021 · PreprintCancer Biology