R. Murugan

Memory B cells dominate the early antibody-secreting cell response to SARS-CoV-2 mRNA vaccination in naive individuals independently of their antibody affinity

Theory on the power-law distribution of the Michaelis-Menten enzyme kinetic parameters

The paper demonstrates that enzyme kinetic parameters follow power-law distributions and validates this with datasets across various enzymes.

Molecular and functional properties of human Plasmodium falciparum CSP C-terminus antibodies

This study characterizes human antibodies targeting the PfCSP C-terminal domain, finding limited protective activity and suggesting exclusion from malaria vaccine design.

Theory on the rate equations of Michaelis-Menten type enzyme kinetics with competitive inhibition

The paper derives refined rate equations for enzyme kinetics with competitive inhibition, showing improved accuracy over standard approximations in certain conditions.

A Lattice Model on the Rate of DNA Hybridization

The paper develops a lattice model to analyze DNA hybridization rates, showing that renaturation depends on sequence complexity and two distinct pathways involving incorrect and trap-correct contacts.

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

This study characterizes a monoclonal antibody against the N-terminal domain of PfCSP, finding it has high affinity but lacks functional inhibitory activity against sporozoites.

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

The paper characterizes 200 human monoclonal PfCSP antibodies, showing that high affinity to a conserved NANP motif, not cross-reactivity, correlates with parasite inhibition and protection.

Theory on the looping mediated directional-dependent propulsion of transcription factors along DNA

This paper proposes a theory explaining how transcription factors propel along DNA through directional-dependent mechanisms to achieve combinatorial transcription activation.

Theory of site-specific DNA-protein interactions in the presence of nucleosome roadblocks

This paper develops a theoretical framework showing how nucleosomes affect transcription factor diffusion and binding, finding that nucleosomes hinder 1D diffusion when between TFs and their sites but can enhance search when between nucleosomes and TFBS.

Theory On The Rate Equation Of Michaelis-Menten Type Single-Substrate Enzyme Catalyzed Reactions

The paper derives analytical solutions for Michaelis-Menten rate equations by introducing a scaling framework and analyzing dynamical regimes and efficiency of enzyme-catalyzed reactions.