Author

D. Oyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4 Biophysics· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:plant (other)· 3 Assay:protein structure· 3 Approach:biophysical modeling· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

I. A. Wilson· 6 shared T. Pholcharee· 4 shared C. R. King· 3 shared J. L. Torres· 3 shared A. B. Ward· 2 shared C. A. Cottrell· 2 shared D. Emerling· 2 shared E. Locke· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersImmunology

I. A. Wilson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Characterization of an amyloidogenic intermediate of transthyretin by NMR relaxation dispersion

B. I. Leach, J. A. Ferguson, G. J. Morgan, X. Sun, G. Kroon, D. Oyen, J. Dyson, P. Wright

This study uses NMR relaxation dispersion to characterize the structural dynamics of an amyloidogenic intermediate of transthyretin, revealing conformational fluctuations that promote amyloid formation.

bioRxiv · Feb 16, 2024Biophysics

An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity that Reverses Carfentanil-Induced Respiratory Depression

L. M. Eubanks, T. Pholcharee, D. Oyen, Y. Natori, B. Zhou, I. A. Wilson, K. D. Janda

This paper develops a human antibody fragment that reverses carfentanil-induced respiratory depression by targeting multiple opioid analogs.

bioRxiv · Jul 4, 2023Pharmacology & Toxicology

Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection

G. Martin, J. L. Torres, T. Pholcharee, D. Oyen, Y. Flores-Garcia, G. Gibson, R. Moskovitz, N. Beutler, D. D. Jung, J. Copps, W.-H. Lee, G. Gonzalez-Paez, D. Emerling, R. S. MacGill, E. Locke, , A. Ward

The paper analyzes structural and functional properties of antibodies targeting PfCSP, showing how homotypic interactions and affinity maturation influence protection against malaria.

bioRxiv · Sep 20, 2022Immunology

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

T. Pholcharee, D. Oyen, Y. Flores-Garcia, G. Gonzalez-Paez, Z. Han, K. L. Williams, W. Volkmuth, D. Emerling, E. Locke, C. R. King, F. Zavala, I. A. Wilson

The paper analyzes eight anti-NANP antibodies from a malaria vaccine trial, linking their structural and biophysical properties to in vivo protection against P. falciparum.

bioRxiv · Jul 18, 2020Microbiology

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

C. A. Cottrell, J. van Schooten, C. A. Bowman, M. Yuan, D. Oyen, M. Shin, R. Morpurgo, P. van der Woude, M. van Breemen, J. L. Torres, R. Patel, J. Gross, L. M. Sewall, J. Copps, G. Ozorowski, , M. J. van Gils

This study maps antibody responses to HIV-1 envelope trimers in non-human primates, identifying strain-specific and conserved epitopes recognized by vaccine-induced antibodies.

bioRxiv · Feb 5, 2020Immunology

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

E. Thai, G. Costa, A. Weyrich, R. Murugan, D. Oyen, K. Prieto, A. Bosch, A. Valleriani, N. C. Wu, T. Pholcharee, S. W. Scally, I. A. Wilson, H. Wardemann, J.-P. Julien, E. A. Levashina

This study characterizes a monoclonal antibody against the N-terminal domain of PfCSP, finding it has high affinity but lacks functional inhibitory activity against sporozoites.

bioRxiv · Jan 13, 2020Immunology

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

D. Oyen, J. L. Torres, C. A. Cottrell, C. R. King, I. A. Wilson, A. B. Ward

The paper presents a cryo-EM structure of Plasmodium falciparum CSP with vaccine-elicited antibodies, revealing a spiral conformation stabilized by inter-antibody contacts.

bioRxiv · May 27, 2018Immunology