Author

E. A. Levashina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Ecology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Research Focus:clustering· 3 Organism:plant (other)· 3 Approach:statistical model· 3 Organism:human· 2 Assay:protein structure· 2

Frequent Co-Authors

G. Costa· 5 shared H. Wardemann· 3 shared J.-P. Julien· 3 shared K. Prieto· 3 shared R. Murugan· 3 shared A. Bosch· 2 shared C. Goosmann· 2 shared E. Thai· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersImmunology

G. Costa

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Larval thermosensitivity shapes adult population dynamics in Anopheles mosquitoes

J. Estupinan, A. M. Weyrich, P. Schloesser, C. Naujoks, M. Gildenhard, A. Diarra, M. Diallo, D. Sangare, A. Telschow, C.-h. Hsieh, E. A. Levashina, P. Carrillo-Bustamante

The paper investigates how larval thermosensitivity affects adult mosquito population dynamics in Anopheles gambiae s.l. using field data, experiments, and modeling.

bioRxiv · Sep 19, 2023 · PreprintEcology

Generation of a Plasmodium falciparum reporter line for studies of parasite biology throughout the life cycle

P. Suarez-Cortes, G. Costa, M. Andres, D. Eyermann, C. Kreschel, L. Spohr, C. Goosmann, V. Brinkmann, E. A. Levashina

This paper generates a new fluorescent reporter parasite strain, PfOBC13GFP, for studying Plasmodium falciparum throughout its life cycle with improved fluorescence and mosquito infectivity.

bioRxiv · May 23, 2023 · PreprintMicrobiology

Molecular and functional properties of human Plasmodium falciparum CSP C-terminus antibodies

O. E. Oludada, G. Costa, C. Burn Aschner, A. Obraztsova, K. Prieto, C. Canetta, S. L. Hoffmann, P. Kremsner, B. Mordmueller, R. Murugan, J.-P. Julien, E. A. Levashina, H. Wardemann

This study characterizes human antibodies targeting the PfCSP C-terminal domain, finding limited protective activity and suggesting exclusion from malaria vaccine design.

bioRxiv · Jan 19, 2023 · PreprintImmunology

Mosquito metabolism shapes life-history strategies of Plasmodium parasites

P. Carrillo-Bustamante, G. Costa, L. Lampe, E. A. Levashina

This study uses a novel individual-based model to show that mosquito metabolism influences Plasmodium parasite life-history strategies, challenging the idea that fast development is optimal for transmission.

bioRxiv · Jul 6, 2022 · PreprintEvolutionary Biology

Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes

G. Volohonsky, P. Paul-Gilloteaux, J. Stafkova, J. Soichot, J. Salamero, E. A. Levashina

The paper tracks Plasmodium parasite invasion in Anopheles mosquitoes using transgenic reporters, revealing species-specific kinetics influenced by the mosquito complement-like system.

bioRxiv · Feb 6, 2020Immunology

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

E. Thai, G. Costa, A. Weyrich, R. Murugan, D. Oyen, K. Prieto, A. Bosch, A. Valleriani, N. C. Wu, T. Pholcharee, S. W. Scally, I. A. Wilson, H. Wardemann, J.-P. Julien, E. A. Levashina

This study characterizes a monoclonal antibody against the N-terminal domain of PfCSP, finding it has high affinity but lacks functional inhibitory activity against sporozoites.

bioRxiv · Jan 13, 2020Immunology

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

R. Murugan, S. W. Scally, G. Costa, G. Mustafa, E. Thai, T. Decker, A. Bosch, K. Prieto, E. A. Levashina, J.-P. Julien, H. Wardemann

The paper characterizes 200 human monoclonal PfCSP antibodies, showing that high affinity to a conserved NANP motif, not cross-reactivity, correlates with parasite inhibition and protection.

bioRxiv · Oct 9, 2019Immunology

Anopheles gambiae TEP1 forms a complex with the coiled-coil domain of LRIM1/APL1C following a conformational change in the thioester domain

R. H. G. Baxter, M. Williams, A. Contet, E. A. Levashina

This paper investigates how allelic variation in TEP1 affects its stability and interaction with LRIM1/APL1C, revealing that conformational changes regulate complex formation and immune function in Anopheles gambiae.

bioRxiv · Feb 14, 2019Immunology

Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging

M. S. Severo, J. J. M. Landry, R. L. Lindquist, C. Goosmann, V. Brinkmann, P. Collier, A. E. Hauser, V. Benes, J. Henriksson, S. A. Teichmann, E. A. Levashina

The paper uses single-cell genomics and imaging to classify mosquito blood cells, revealing transcriptional signatures and challenges to current morphology-based classification.

bioRxiv · Dec 22, 2017Immunology