G. Costa

Generation of a Plasmodium falciparum reporter line for studies of parasite biology throughout the life cycle

This paper generates a new fluorescent reporter parasite strain, PfOBC13GFP, for studying Plasmodium falciparum throughout its life cycle with improved fluorescence and mosquito infectivity.

Molecular and functional properties of human Plasmodium falciparum CSP C-terminus antibodies

This study characterizes human antibodies targeting the PfCSP C-terminal domain, finding limited protective activity and suggesting exclusion from malaria vaccine design.

A first-in-class Wiskott-Aldrich syndrome protein (WASp) activator with anti-tumor activity in hematological cancers

This paper develops EG-011, a first-in-class WASp activator with anti-tumor activity in hematological cancers, including resistant models.

Mapping the content of comments on bioRxiv and medRxiv preprints

The paper analyzes comments on bioRxiv and medRxiv preprints to assess their content and compare it to traditional peer review.

Mosquito metabolism shapes life-history strategies of Plasmodium parasites

This study uses a novel individual-based model to show that mosquito metabolism influences Plasmodium parasite life-history strategies, challenging the idea that fast development is optimal for transmission.

Large-scale deployment and establishment of Wolbachia into the Aedes aegypti population in Rio de Janeiro, Brazil.

This study reports the large-scale release of Wolbachia-infected Aedes aegypti mosquitoes in Brazil, showing successful invasion with infection rates of 30-70% in two areas.

Eco-ethology and trait distribution of two congeneric species - different strategies for the plague pest Acanthoplus discoidalis and the long-legged A. longipes (Orthoptera: Tettigoniidae)

The paper compares trait distributions between two congeneric cricket species to determine if interspecific or intraspecific variation drives differences in body measurements.

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

This study characterizes a monoclonal antibody against the N-terminal domain of PfCSP, finding it has high affinity but lacks functional inhibitory activity against sporozoites.

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

The paper characterizes 200 human monoclonal PfCSP antibodies, showing that high affinity to a conserved NANP motif, not cross-reactivity, correlates with parasite inhibition and protection.

Population structure determined by comparative amplicon gene sequencing in biofilm and planktonic bacterial communities from pesticide-contaminated water

The paper uses 16S rRNA gene sequencing to compare bacterial population structure in planktonic and biofilm communities from pesticide-contaminated water, finding greater diversity in biofilms due to adaptation to stressful conditions.

Non-competitive resource exploitation within-mosquito shapes evolution of malaria virulence

This study shows that mosquito lipid trafficking affects Plasmodium virulence by shaping sporozoite development and metabolic activity, revealing a vector-driven mechanism in malaria virulence evolution.