Author

R. Muthuswamy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. Odunsi· 2 shared S. Battaglia· 2 shared A. Amobi-McCloud· 1 shared A. Lugade· 1 shared A. Miliotto· 1 shared A. R. McGray· 1 shared B. D. Litchy· 1 shared C. A. Eppolito· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

K. Odunsi

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2 papers

Recent·Most cited

Indoleamine 2,3-dioxygenase upregulates PD-1 expression on ovarian tumor infiltrating CD8+ T cells via kynurenine activation of the aryl hydrocarbon receptor

A. Amobi-McCloud, R. MUTHUSWAMY, S. Battaglia, H. Yu, T. Liu, J. Wang, V. Putluri, P. K. Singh, F. Qian, R.-Y. Huang, N. Putluri, T. Takemasa, A. Lugade, S. Liu, K. Odunsi

This study shows that IDO1 promotes PD-1 expression on CD8+ T cells in ovarian tumors through kynurenine-mediated AHR activation, suggesting therapeutic targeting of these pathways.

bioRxiv · Feb 18, 2021 · PreprintImmunology

CXCR6 by increasing retention of memory CD8 T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer

R. Muthuswamy, A. R. McGray, S. Battaglia, W. He, A. Miliotto, C. A. Eppolito, B. D. Litchy, P. Shrikant, K. Odunsi, K. Odunsi

This study identifies CXCR6 as a marker for resident memory CD8 T cells in ovarian cancer, showing its role in enhancing tumor immunosurveillance through increased retention of these cells in the tumor microenvironment.

bioRxiv · Dec 2, 2020Immunology