Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation
A. R. Cruz, M. A. den Boer, J. Strasser, F. J. Beurskens, C. J. C. de Haas, P. Aerts, G. Wang, R. N. de Jong, F. Bagnoli, J. van Strijp, K. P. M. van Kessel, J. Schuurman, J. Preiner, A. J. R. Heck, S. H. M. Rooijakkers
This study shows Staphylococcal protein A inhibits IgG hexamer formation, blocking complement activation, but IgG3 can still induce complement activation despite SpA.
bioRxiv · Jul 20, 2020Microbiology