L. Hoekman

Caskin2 is a novel talin and Abi1-binding protein that promotes cell motility

This study identifies Caskin2 as a novel talin-binding protein that enhances cell motility through interactions with Abi1 and the WAVE Regulatory Complex.

An "alert state" ribosome population acts as a master regulator of cytokine mediated processes

The paper identifies an 'alert-state' ribosome subpopulation (ASRs) that regulates cytokine-mediated processes by preferentially translating key mRNAs involved in immune responses.

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator

This study uses a CRISPR screen to identify genes critical for macrophage-mediated killing of prostate cancer cells, revealing AR as an immunomodulator that promotes resistance to macrophage attack.

Glucocorticoids regulate cancer cell dormancy

This study identifies the mechanism by which glucocorticoid receptor activation induces cancer cell dormancy through CDKN1C and FOXO1/IRS2 signaling, with implications for cancer therapy.

Evolutionarily-conserved chromatin crosstalk generates a DOT1L-dose dependency in thymic lymphoma caused by loss of HDAC1

The paper identifies an evolutionarily-conserved interaction between HDAC1 and DOT1L that influences H3K79 methylation and contributes to thymic lymphoma development.

Mechanisms of integrin αVβ5 clustering in flat clathrin lattices

This study identifies molecular mechanisms governing integrin αVβ5 clustering in flat clathrin lattices in human keratinocytes, showing dependence on vitronectin, calcium, and adaptor proteins.