Tumor-responsive, multifunctional CAR-NK cells cooperate with impaired autophagy to infiltrate and target glioblastoma
J. Wang, S. Torregrosa-Allen, B. D. Elzey, S. Utturkar, N. A. Lanman, V. Bernal-Crespo, M. M. Behymer, G. T. Knipp, Y. Yun, M. C. Veronesi, A. L. Sinn, K. E. Pollok, R. R. Brutkiewicz, K. S. Nevel, S. Matosevic
This study develops multifunctional CAR-NK cells that target glioblastoma by addressing antigen escape, poor immune cell homing, and immunometabolic suppression through tumor-specific antibody fragments and autophagy inhibition.
bioRxiv · Oct 7, 2020 · PreprintImmunology