Author

K. E. Pollok

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. C. Veronesi· 2 shared Y. Yun· 2 shared A. Chong· 1 shared A. L. Sinn· 1 shared B. D. Elzey· 1 shared B. Qiu· 1 shared B.-Y. Li· 1 shared C. R. Weber· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

M. C. Veronesi

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Author profile →

5 papers

Recent·Most cited

Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins

K. Li, Q. Huo, N. H. Dimmitt, G. Qu, J. Bao, P. H. Pandya, M. R. Saadatzadeh, K. Bijangi-Vishehsaraei, M. A. Kacena, K. E. Pollok, C.-C. Lin, B.-Y. Li, H. Yokota

The paper identifies osteosarcoma-enriched transcripts that encode extracellular tumor-suppressing proteins, suggesting a paradoxical therapeutic strategy using OS transcriptomes.

eLife · Mar 21, 2023Peer-reviewedCancer Biology

A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer

Q. Tian, P. Zhang, Y. Wang, Y. Si, D. Yin, C. R. Weber, M. Fishel, K. E. Pollok, B. Qiu, F. Xiao, A. Chong

This paper describes a novel triptolide analog, CK21, which downregulates the NF-κB pathway and induces mitochondrial apoptosis in human pancreatic cancer cells.

bioRxiv · Feb 15, 2023Pharmacology & Toxicology

Chemical exhaustion of RPA in cancer treatment

P. S. VanderVere-Carozza, K. S. Pawelczak, N. S. Gavande, S. I. Jalal, K. E. Pollok, E. Ekinci, J. Heyza, S. M. Patrick, J. J. Turchi

This paper develops RPA inhibitors that induce RPA exhaustion, showing anticancer activity in vitro and in vivo, and identifies RPA expression as a prognostic and predictive biomarker.

bioRxiv · Nov 30, 2020 · PreprintCancer Biology

Development of Targetable Multi-Drug Nanoparticles for Glioblastoma Treatment and In Vitro Evaluation in Glioblastoma Stem Cells

S. B. Smiley, Y. Yun, P. Ayyagari, H. E. Shannon, K. E. Pollok, M. W. Vannier, S. K. Das, M. C. Veronesi

This paper develops multi-drug nanoparticles targeting GBM stem cells and evaluates their in vitro efficacy against these cells.

bioRxiv · Nov 8, 2020 · PreprintCell Biology

Tumor-responsive, multifunctional CAR-NK cells cooperate with impaired autophagy to infiltrate and target glioblastoma

J. Wang, S. Torregrosa-Allen, B. D. Elzey, S. Utturkar, N. A. Lanman, V. Bernal-Crespo, M. M. Behymer, G. T. Knipp, Y. Yun, M. C. Veronesi, A. L. Sinn, K. E. Pollok, R. R. Brutkiewicz, K. S. Nevel, S. Matosevic

This study develops multifunctional CAR-NK cells that target glioblastoma by addressing antigen escape, poor immune cell homing, and immunometabolic suppression through tumor-specific antibody fragments and autophagy inhibition.

bioRxiv · Oct 7, 2020 · PreprintImmunology