Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelination
Darpan Saraswat, Hani J. Shayya, Jessie J. Polanco, Ajai K. Tripathi, R. Ross Welliver, Suyog U. Pol, Richard A. Seidman, Jacqueline E. Broome, Melanie A. O’Bara, Toin H. Van Kuppevelt, Joanna J. Phillips, Ranjan Dutta, Fraser J. Sim
This study identifies Sulf1/2 as a key inhibitor of oligodendrocyte progenitor cell recruitment and remyelination in chronic demyelination, showing that sulfatase inhibition can enhance remyelination.
Nature Communications · Mar 26, 2021Peer-reviewedNeuroscience