R. Sankaranarayanan

A translation proofreader of archaeal origin imparts multialdehyde stress tolerance to land plants

This study shows that the archaeal DTD2 enzyme protects plants from aldehyde toxicity by removing harmful adducts on tRNA, and its overexpression enhances aldehyde resistance in Arabidopsis.

DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

This study identifies DIP2 as a regulator of specific diacylglycerol (DAG) subsets in yeast, fly, and mouse, showing its role in preventing toxic DAG accumulation and modulating lipid homeostasis.

Rice Bran and Quercetin Produce a Positive Synergistic Effect on Human Gut Microbiota, Elevate the Level of Propionate, and Reduce the Population of Enterobacteriaceae family when Determined using a Bioreactor Model.

A universal pocket in FAALs ensures redirection of fatty acid pool away from CoA-based activation

The paper identifies a unique binding pocket in FAALs that allows them to selectively use holo-ACP over CoA, enabling CoA-independent fatty acid activation and lipid biosynthesis.

Recruitment of Archaeal DTD is a Key Event in the Emergence of Land Plants

The paper identifies DTD2, an archaeal-derived gene, as critical for plant adaptation to land by detoxifying acetaldehyde through NEDAT deacylation.

A discriminator code-based DTD surveillance ensures faithful glycine delivery for protein biosynthesis in bacteria

The paper shows DTD discriminates tRNA discriminator bases to ensure correct glycine delivery in bacteria, with eukaryotic DTD using inverted specificity.

A Chiral Selectivity Relaxed Paralog Of DTD For Proofreading tRNA Mischarging In Animalia

The paper identifies ATD, a chiral-selective variant of DTD in Animalia, which proofreads L-alanine mischarged on tRNA and is conserved across Chordata.