ImmunologyeLifePeer-reviewed
A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis
DOI 10.7554/elife.93273.3
Author
R. S. Gokhale
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2019-2024 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 25 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- Cell BiologybioRxivPreprint
Melanocytes Exhibit Distinct Cell States Governed by A Gene Regulatory Network Under Stochastic Influence
A. AGGARWAL, A. Nasreen, S. Sahoo…·V. T. Natarajan
The paper identifies distinct melanocyte states and shows stochastic gene expression and epigenetic modification enable their co-existence and response to environmental cues.
DOI 10.1101/2023.05.10.540111 - Cell BiologybioRxivPreprint
Sustained pigmentation causes DNA damage and invokes translesion polymerase Pol κ for repair in melanocytes
V. Natarajan, S. Khanna, M. Ghazi…·R. S. Gokhale
This study shows sustained melanogenesis causes DNA damage in melanocytes, invokes Pol κ for repair, and links Pol κ activity to genome instability and mutational load in melanoma.
- BiochemistrybioRxiv
A universal pocket in FAALs ensures redirection of fatty acid pool away from CoA-based activation
G. S. Patil, P. Kinatukara, S. Mondal…·R. Sankaranarayanan
The paper identifies a unique binding pocket in FAALs that allows them to selectively use holo-ACP over CoA, enabling CoA-independent fatty acid activation and lipid biosynthesis.
DOI 10.7554/elife.70067 - Cell BiologybioRxivPreprint
Temporal resolution of melanogenesis determine fatty acid metabolism as key skin pigment regulator
R. S. Gokhale, F. Sultan, R. BASU…·V. Natarajan
The paper identifies fatty acid metabolism as a key regulator of melanogenesis by analyzing temporal metabolic and transcriptional changes in melanocytes.
DOI 10.1101/2021.04.06.438588 - Cell BiologybioRxivPreprint
kinesin recruitment by adapter SKIP on melanosomes is dynamically controlled by LC3B phosphorylation
Y. J. Subramaniam, D. Murthy, A. D. Raja…·V. Natarajan
This study identifies KIF1B as a novel kinesin motor for melanosome transport and shows that LC3B phosphorylation by PKA enhances anterograde movement in response to -MSH.
DOI 10.1101/2021.03.11.434917 - Cell BiologybioRxiv
pH controlled histone acetylation amplifies melanocyte differentiation program downstream of MITF
V. Natarajan, D. A. Raja, V. Gotherwal…·R. S. Gokhale
The paper identifies a pH-controlled histone acetylation mechanism downstream of MITF that amplifies melanocyte differentiation by modulating chromatin dynamics.