Author

R. Sasisekharan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Assay:structural biology· 2 Organism:virus· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:large language model· 1

Frequent Co-Authors

R. Raman· 3 shared T. Clark· 3 shared N. L. Miller· 2 shared A. Jayaraman· 1 shared A. Viglione· 1 shared E. Fitzpatrick· 1 shared K. Tharakaraman· 1 shared N. Pentakota· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBioengineering

R. Raman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Machine Learning-Guided Antibody Engineering That Leverages Domain Knowledge To Overcome The Small Data Problem

T. Clark, V. Subramanian, A. Jayaraman, E. Fitzpatrick, R. Gopal, N. Pentakota, T. Rurak, S. Anand, A. Viglione, K. Tharakaraman, R. Raman, R. Sasisekharan

This paper presents a machine learning platform that enhances antibody affinity and neutralizing potency using domain knowledge and limited experimental data.

bioRxiv · Jun 2, 2023 · PreprintBioengineering

A structural dynamic explanation for observed escape of SARS-CoV-2 BA.2 variant mutation S371L/F

N. L. Miller, T. Clark, R. Raman, R. Sasisekharan

The paper explains the broad immune escape of SARS-CoV-2 BA.2 variant mutations S371L/F through structural analysis of spike trimer conformational dynamics.

bioRxiv · Feb 25, 2022 · PreprintMicrobiology

Mapping Potential Antigenic Drift Sites (PADS) on SARS-CoV-2 Spike in Continuous Epitope-Paratope Space

N. L. Miller, T. Clark, R. Raman, R. Sasisekharan

The paper identifies potential antigenic drift sites on SARS-CoV-2 spike protein and projects them into epitope-paratope space to assess mutation synergy across variants of concern.

bioRxiv · Jun 7, 2021 · PreprintImmunology