Microglia mediate contact-independent neuronal pruning via secreted Neuraminidase-3 associated with extracellular vesicles
C. S. Delaveris, C. L. Wang, N. M. Riley, S. Li, R. U. Kulkarni, C. R. Bertozzi
This study shows that microglia secrete Neuraminidase-3 via extracellular vesicles to prune neurons contact-independently, disrupting network connectivity and contributing to neuroinflammatory diseases.
bioRxiv · Aug 21, 2023 · PreprintBiochemistry