Author

N. M. Riley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 6 Research Focus:cell type annotation· 5 Organism:human· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

C. R. Bertozzi· 6 shared D. J. Shon· 2 shared K. Pedram· 2 shared S. A. Malaker· 2 shared A. Bermudez· 1 shared A. C. Yang· 1 shared A. Dillin· 1 shared A. E. Lefebvre· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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6 shared papersBiochemistry

C. R. Bertozzi

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Microglia mediate contact-independent neuronal pruning via secreted Neuraminidase-3 associated with extracellular vesicles

C. S. Delaveris, C. L. Wang, N. M. Riley, S. Li, R. U. Kulkarni, C. R. Bertozzi

This study shows that microglia secrete Neuraminidase-3 via extracellular vesicles to prune neurons contact-independently, disrupting network connectivity and contributing to neuroinflammatory diseases.

bioRxiv · Aug 21, 2023 · PreprintBiochemistry

The microenvironment dictates glycocalyx construction and immune surveillance

K. Tharp, S. Park, G. A. Timblin, A. Richards, J. Berg, N. Twells, N. M. Riley, E. Peltan, D. J. Shon, E. Stevenson, C. K. Tsui, F. Palomba, A. E. Lefebvre, R. Soens, N. Ayad, , V. Weaver

This study shows that the physical properties of the microenvironment influence glycocalyx composition and immune surveillance in vitro using physiologically relevant models.

bioRxiv · Jun 23, 2023 · PreprintCell Biology

Antibody-lectin chimeras for glyco-immune checkpoint blockade

J. C. Stark, M. A. Gray, S. Wisnovsky, I. Ibarlucea-Benitez, M. Lustig, N. M. Riley, M. K. Ribi, W. J. Errington, B. Bruncsics, C. A. Sarkar, T. Valerius, J. V. Ravetch, C. R. Bertozzi

This paper introduces antibody-lectin chimeras (AbLecs) as a new immunotherapy approach that blocks glyco-immune checkpoints, enhancing cancer immune responses and synergizing with existing checkpoint inhibitors.

bioRxiv · Oct 26, 2022Bioengineering

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

K. Pedram, D. J. Shon, G. S. Tender, N. R. Mantuano, J. J. Northey, K. J. Metcalf, S. P. Wisnovsky, N. M. Riley, G. C. Forcina, S. A. Malaker, A. Kuo, B. M. George, C. L. Miller, K. M. Casey, J. G. Vilches-Moure, , C. R. Bertozzi

This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.

bioRxiv · May 20, 2022Biochemistry

Multi-Omics Analysis of Fibroblasts from the Invasive Tumor Edge Reveals that Tumor-Stroma Crosstalk Induces O-glycosylation of the CDK4-pRB Axis

G. Bouchard, F. J. G. Marques, L. G. Karacosta, W. Zhang, A. Bermudez, N. M. Riley, L. C. Mehl, J. A. Benson, J. B. Shrager, C. R. Bertozzi, S. Pitteri, A. J. Giaccia, S. K. Plevritis

The paper analyzes multi-omics data from fibroblasts at the tumor edge and core to show O-glycosylation of the CDK4-pRB axis is induced by tumor-stroma crosstalk.

bioRxiv · May 28, 2021 · PreprintCancer Biology

Revealing the human mucinome

S. A. Malaker, N. M. Riley, J. Shon, K. Pedram, V. Krishnan, O. Dorigo, C. R. Bertozzi

This study develops a mucinomics platform using an inactive mucinase to enrich and identify mucin-domain glycoproteins, revealing molecular signatures in cancer samples.

bioRxiv · Jan 27, 2021Biochemistry

Cell type-selective secretome profiling in vivo

W. Wei, N. M. Riley, A. C. Yang, J. T. Kim, S. M. Terrell, V. L. Li, M. Garcia-Contreras, C. R. Bertozzi, J. Z. Long

The paper introduces a method to profile cell-type-specific secretomes in vivo and identifies novel secreted proteins and dynamic changes in hepatocyte secretomes.

bioRxiv · Sep 18, 2020Biochemistry

Broad and thematic remodeling of the surface glycoproteome on isogenic cells transformed with driving proliferative oncogenes

K. K. Leung, G. M. Wilson, L. L. Kirkemo, N. M. Riley, J. J. Coon, J. A. Wells

This study uses proteomics to show how six oncogenes remodel the surface glycoproteome of breast cells, with common functional themes reversed by MEK inhibition.

bioRxiv · Oct 17, 2019Biochemistry