Author

R. V. Aroian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

D. Gazzola· 3 shared H. Li· 3 shared Y. Hu· 3 shared A. Abraham· 2 shared E. Soto· 2 shared F. Rus· 2 shared J. F. Urban· 2 shared K. Flanagan· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

D. Gazzola

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An efficient method for viable cryopreservation of hookworms and other gastrointestinal nematodes in the laboratory

H. Li, D. Gazzola, Y. Hu, R. V. Aroian

The paper describes a method for long-term cryopreservation and recovery of hookworms and other gastrointestinal nematodes, enabling better laboratory research and global health applications.

bioRxiv · Feb 1, 2023 · PreprintImmunology

A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins

A. Sitaram, Y. Yin, T. Zamaitis, B. Zhang, R. V. Aroian

This paper identifies a novel C. elegans pathway involving nck-1 and the actin cytoskeleton that mediates defense against bacterial pore-forming proteins, independent of MAPK signaling.

bioRxiv · Jun 10, 2022Microbiology

Purified cytosolic crystals from Bacillus thuringiensis as a novel active pharmaceutical ingredient (API)

J. Chicca, N. R. Cazeault, F. Rus, A. Abraham, C. Garceau, H. Li, S. M. Atwa, K. Flanagan, E. Soto, M. S. Morrison, D. Gazzola, Y. Hu, D. R. Liu, M. K. Nielsen, J. F. Urban, , R. V. Aroian

This paper describes the scalable purification of Bt Cry5B crystals and demonstrates their potent bioactivity against nematodes in vitro and in vivo.

bioRxiv · May 20, 2022 · PreprintMicrobiology

Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans

H. Li, A. Abraham, D. Gazzola, Y. Hu, G. Beamer, K. Flanagan, E. Soto, F. Rus, Z. Mirza, A. Draper, S. Vakalapudi, C. Stockman, P. Bain, J. F. Urban, G. R. Ostroff, R. V. Aroian

This paper develops a safe, effective, and scalable anthelmintic based on Bacillus thuringiensis Cry5B for treating human gastrointestinal nematodes.

bioRxiv · Sep 2, 2020Microbiology