Author

R. van Dalen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Peschel· 3 shared C. Rademacher· 2 shared F. F. Fuchsberger· 2 shared A. Hendriks· 1 shared A. M. A. Elsherbini· 1 shared B. Del Frari· 1 shared C. J. C. de Haas· 1 shared C. J. Slavetinsky· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

A. Peschel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The capsular polysaccharide obstructs wall teichoic acid functions in Staphylococcus aureus

E. Lehmann, R. van Dalen, L. Gritsch, C. J. Slavetinsky, N. Korn, C. Rohmer, D. Krause, A. Peschel, C. Weidenmaier, C. Wolz

The paper investigates how capsular polysaccharide (CP) in Staphylococcus aureus affects wall teichoic acid (WTA) functions, finding that CP interferes with WTA-mediated processes like phage binding and adhesion but enhances virulence.

bioRxiv · Jul 26, 2023 · PreprintMicrobiology

Targeting of the human nasal microbiota by secretory IgA antibodies

R. van Dalen, A. M. A. Elsherbini, M. Harms, S. Alber, R. Stemmler, A. Peschel

This study identifies bacterial genera and species targeted by sIgA in the nasal microbiome using IgA-seq and sIgA deposition experiments, showing individual variation and epitope-independent interactions with S. aureus.

bioRxiv · Aug 31, 2022 · PreprintMicrobiology

The impact of Staphylococcus aureus cell wall glycosylation on langerin recognition and Langerhans cell activation

A. Hendriks, R. van Dalen, S. Ali, D. Gerlach, G. A. van der Marel, F. F. Fuchsberger, P. Aerts, C. J. C. de Haas, A. Peschel, C. Rademacher, J. van Strijp, J. D. Codee, N. M. van Sorge

This study investigates how different glycosylation patterns on Staphylococcus aureus cell walls affect langerin recognition and Langerhans cell activation, finding that β-GlcNAc is sufficient for langerin binding regardless of its position on WTA.

bioRxiv · Nov 6, 2020Microbiology

A specific, glycomimetic Langerin ligand for human Langerhans cell targeting

E.-C. Wamhoff, J. Schulze, L. Bellmann, G. Bachem, F. F. Fuchsberger, J. Rademacher, M. Hermann, B. Del Frari, R. van Dalen, D. Hartmann, N. van Sorge, O. Seitz, P. Stoitzner, C. Rademacher

The paper develops a glycomimetic Langerin ligand for targeting Langerhans cells, enabling efficient antigen and adjuvant delivery for cancer vaccines.

bioRxiv · Mar 31, 2018Immunology