Author

C. Rademacher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

F. F. Fuchsberger· 4 shared R. van Dalen· 3 shared A. Peschel· 2 shared E.-C. Wamhoff· 2 shared N. M. van Sorge· 2 shared A. Caflisch· 1 shared A. Hendriks· 1 shared B. Del Frari· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMicrobiology

F. F. Fuchsberger

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Author profile →

5 papers

Recent·Most cited

Information transfer in mammalian glycan-based communication

F. F. Fuchsberger, D. Kim, M. Kagelmacher, R. Wawrzinek, C. Rademacher

The paper investigates how glycan-lectin communication pathways transmit information, finding that dectin-2 is an inefficient receptor but its signal can be enhanced by co-receptor overexpression.

bioRxiv · May 10, 2021Cell Biology

The impact of Staphylococcus aureus cell wall glycosylation on langerin recognition and Langerhans cell activation

A. Hendriks, R. van Dalen, S. Ali, D. Gerlach, G. A. van der Marel, F. F. Fuchsberger, P. Aerts, C. J. C. de Haas, A. Peschel, C. Rademacher, J. van Strijp, J. D. Codee, N. M. van Sorge

This study investigates how different glycosylation patterns on Staphylococcus aureus cell walls affect langerin recognition and Langerhans cell activation, finding that β-GlcNAc is sufficient for langerin binding regardless of its position on WTA.

bioRxiv · Nov 6, 2020Microbiology

Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular pattern that is recognized by langerin (CD207) on skin Langerhans cells

R. van Dalen, J. S. De La Cruz Diaz, M. Rumpret, F. F. Fuchsberger, N. H. van Teijlingen, J. Hanske, C. Rademacher, T. B. H. Geijtenbeek, J. A. G. Van Strijp, C. Weidenmaier, A. Peschel, D. H. Kaplan, N. M. van Sorge

This study shows that S. aureus wall teichoic acid is recognized by langerin on human Langerhans cells, driving Th1/Th17 responses and inflammation in skin diseases.

bioRxiv · Oct 17, 2018 · PreprintMicrobiology

A specific, glycomimetic Langerin ligand for human Langerhans cell targeting

E.-C. Wamhoff, J. Schulze, L. Bellmann, G. Bachem, F. F. Fuchsberger, J. Rademacher, M. Hermann, B. Del Frari, R. van Dalen, D. Hartmann, N. van Sorge, O. Seitz, P. Stoitzner, C. Rademacher

The paper develops a glycomimetic Langerin ligand for targeting Langerhans cells, enabling efficient antigen and adjuvant delivery for cancer vaccines.

bioRxiv · Mar 31, 2018Immunology

Discovery of BAZ2A Bromodomain Ligands

D. Spiliotopoulos, E.-C. Wamhoff, G. Lolli, C. Rademacher, A. Caflisch

The paper identifies BAZ2A bromodomain ligands through high-throughput screening and validates their binding using NMR and crystal structures.

bioRxiv · Jun 7, 2017Biochemistry