R. W. Sayaman

The paper identifies age-related gene expression changes in luminal epithelial cells that contribute to breast cancer susceptibility and develops a classifier to distinguish normal from cancer tissue.

The paper sequences mRNA from twelve purified human breast cell types to identify differentially expressed genes and biological pathways, providing insights into normal cell and tissue function.

The paper presents a method to identify, isolate, and culture twelve major human breast cell types using FACS and creates primary cell models for studying breast tissue interactions.

The paper shows how age-related epigenetic and gene expression changes in mammary luminal epithelia prime cells for cancer initiation, with implications for subtype-specific cancer susceptibility.

The paper profiles the proteome of human mammary epithelia across age and lineage, identifying age-related protein changes and potential therapeutic targets for breast cancer.

This study identifies germline genetic variants associated with immune traits in cancer, revealing their impact on the tumor immune microenvironment.