Author

M. A. LaBarge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. E. Todhunter· 3 shared M. Miyano· 3 shared R. W. Sayaman· 3 shared S. Shalabi· 3 shared A. Zirbes· 2 shared D. E. Schones· 2 shared L. L. Sohn· 2 shared M. R. Stampfer· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

M. E. Todhunter

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Configurational entropy is an intrinsic driver of tissue structural heterogeneity

V. Srivastava, J. L. Hu, J. C. Garbe, B. Veytsman, S. F. Shalabi, D. Yllanes, M. Thomson, M. A. LaBarge, G. Huber, Z. J. Gartner

The paper uses human mammary organoids to show that configurational entropy drives tissue structural heterogeneity by linking structural parameters to molecular and microenvironmental factors.

bioRxiv · Jul 1, 2023 · PreprintBioengineering

Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

R. W. Sayaman, M. Miyano, P. Senapati, A. Zirbes, S. Shalabi, M. E. Todhunter, V. Seewaldt, S. L. Neuhausen, M. R. Stampfer, D. E. Schones, M. A. LaBarge

The paper identifies age-related gene expression changes in luminal epithelial cells that contribute to breast cancer susceptibility and develops a classifier to distinguish normal from cancer tissue.

bioRxiv · Sep 22, 2022Cancer Biology

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

K. Nee, D. Ma, Q. H. Nguyen, N. Pervolarakis, J. Insua-Rodriguez, M. Pein, Y. Gong, G. Hernandez, H. Alshetaiwi, J. Williams, M. Rauf, K. R. Dave, K. Boyapati, C. Calderon, A. Markaryan, , K. Kessenbrock

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

bioRxiv · Oct 20, 2021 · PreprintCancer Biology

Evaluating sources of technical variability in the mechano-node-pore sensing pipeline and their effect on the reproducibility of single-cell mechanical phenotyping

B. Li, K. L. Cotner, N. K. Liu, S. Hinz, M. A. LaBarge, L. L. Sohn

This study evaluates technical variability in a single-cell mechanical phenotyping platform and shows high reproducibility across different labs and users.

bioRxiv · Jun 2, 2021Bioengineering

Epigenetic changes with age primes mammary luminal epithelia for cancer initiation

R. W. Sayaman, M. Miyano, P. Senapati, S. Shalabi, A. Zirbes, M. E. Todhunter, V. Seewaldt, S. L. Neuhausen, M. R. Stampfer, D. E. Schones, M. A. LaBarge

The paper shows how age-related epigenetic and gene expression changes in mammary luminal epithelia prime cells for cancer initiation, with implications for subtype-specific cancer susceptibility.

bioRxiv · Feb 12, 2021 · PreprintCancer Biology

Deep Proteome Profiling of Human Mammary Epithelia at Lineage and Age Resolution

S. Hinz, A. Manousopoulou, M. Miyano, R. W. Sayaman, K. Y. Aguilera, M. E. Todhunter, J. C. Lopez, L. L. Sohn, L. D. Wang, M. A. LaBarge

The paper profiles the proteome of human mammary epithelia across age and lineage, identifying age-related protein changes and potential therapeutic targets for breast cancer.

bioRxiv · Feb 2, 2021Cell Biology