D. Bedognetti

Biological modifications of the immune response to COVID-19 vaccine in patients treated with rituximab and immune-checkpoint inhibitors

This study examines how rituximab and immune-checkpoint inhibitors affect immune responses to a COVID-19 booster vaccine, finding rituximab impairs interferon response and ICI maintains normal immune profiles.

A Community Challenge to Predict Clinical Outcomes After Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

The paper evaluates predictive models for immune checkpoint inhibitor outcomes in NSCLC using clinical trial data from two RCTs, finding that models combining PD-L1, TMB, and immune signatures outperform single biomarkers.

Modulation of SLFN11 induces changes in DNA Damage response

This study shows that increasing SLFN11 expression through CRISPR-dCas9 systems enhances DNA damage response sensitivity in breast cancer cells.

High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infection

This study uses high-temporal-resolution transcriptome profiling to compare interferon responses after mRNA vaccination and SARS-CoV-2 infection, identifying distinct signatures linked to immune outcomes.

The Immune landscape of solid pediatric tumors.

This study characterizes immune subtypes in solid pediatric tumors using gene expression data, finding distinct immune signatures and survival associations.

SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in ovarian cancer

The paper quantifies SLFN11 in ovarian cancer tissues and shows its expression in immune cells, linking it to favorable outcomes and cancer-immunity interactions related to platinum sensitivity.

A modular framework for the development of targeted Covid-19 blood transcript profiling panels

The paper develops a modular framework for designing targeted blood transcript profiling panels to study the immune response to SARS-CoV-2 infection.

Identification of erythroid cell positive blood transcriptome phenotypes associated with severe respiratory syncytial virus infection

The paper identifies erythroid cell-associated blood transcriptome phenotypes linked to severe RSV infection using meta-analysis of public datasets.

Pazopanib induces dramatic but transient contraction of myeloid suppression compartment in favor of adaptive immunity

This study shows pazopanib reduces myeloid suppression and boosts adaptive immunity in mRCC patients, with effects peaking at 3 months.

Development and Characterization of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States

The paper develops a fixed repertoire of blood transcriptome modules based on co-expression patterns across immunological states to provide a stable framework for analyzing and interpreting blood transcriptome data.

Germline genetic contribution to the immune landscape of cancer

This study identifies germline genetic variants associated with immune traits in cancer, revealing their impact on the tumor immune microenvironment.

Genomic landscape of tumor-host interactions with differential prognostic and predictive connotations

The paper analyzes tumor-host interactions across 31 cancer types using the ICR signature to identify prognostic and predictive implications of immune phenotypes.

Elevation of FAM129A in neutrophils exposed to serum of patients with severe sepsis: in silico investigations during a hands on training workshop and follow on validation of protein expression in neutrophils

The paper investigates FAM129A expression in neutrophils exposed to sepsis serum using transcriptome data and confirms surface expression through bench validation.

The abundance of Nudix hydrolase 16 transcripts is elevated in human sepsis: perspectives gained during a hands-on reductionist investigation workshop.

The paper investigates NUDT16 transcript abundance in sepsis using omics data and public datasets, finding elevated levels in septic patients compared to controls.