Author

Rachel C. Weiss

Saint Louis University

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Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Gary J. PattiiD· 1 shared Jonathan S. FisheriD· 1 shared Kelly D. PylesiD· 1 shared Kevin ChoiD· 1 shared Kyle S. McCommisiD· 1 shared Michelle BrennaniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperPhysiology

Gary J. PattiORCID

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1 paper

Recent·Most cited

Loss of mitochondrial pyruvate transport initiates cardiac glycogen accumulation and heart failure

Rachel C. Weiss, Kelly D. Pyles, Kevin Cho, Michelle Brennan, Jonathan S. Fisher, Gary J. Patti, Kyle S. McCommis

This study shows that loss of the mitochondrial pyruvate carrier in the heart leads to glycogen accumulation and heart failure, which can be reversed by inhibiting glycogen synthesis or a ketogenic diet.

Physiology · May 1, 2025Peer-reviewedPhysiology