Designed nanofiber immunogens prime antibody responsesto diverse conformations of the HIV-1 fusion peptide
Chelsea N. Fries, Jui-Lin Chen, Nicole L. Votaw, Benjamin James Cossette, Emily F. Roe, Maria L. Dennis, Elizabeth J. Curvino, Luqman A. Issah, K. Lázár, Shamitha Shetty, Rachel Katz, Corrine A. Nief, Sallie R. Permar, Koen K. A. Van Rompay, Genevieve G. Fouda, Joel H. Collier
This paper introduces a designed nanofiber immunogen platform that primes antibodies with increased conformational tolerance toward HIV-1 fusion peptide, showing efficacy in mice and infant non-human primates.
bioRxiv · Oct 5, 2026 · PreprintBioengineering