Koen K. A. Van Rompay

Designed nanofiber immunogens prime antibody responsesto diverse conformations of the HIV-1 fusion peptide

This paper introduces a designed nanofiber immunogen platform that primes antibodies with increased conformational tolerance toward HIV-1 fusion peptide, showing efficacy in mice and infant non-human primates.

Commensal bacteria inhibit viral infections via a tryptophan metabolite

The paper identifies a mechanism by which commensal bacteria inhibit viral infections through a tryptophan metabolite that activates the aryl hydrocarbon receptor.

Germline-targeting HIV Envelope SOSIP immunization more frequently elicits broadly-neutralizing antibody precursor responses in infant compared to juvenile rhesus macaques

This study compares bnAb precursor responses in infant and juvenile rhesus macaques after germline-targeting HIV Env immunization, finding higher rates in infants.

Rhesus macaques model human Mayaro virus disease and transmit to Aedes aegypti mosquitoes

This study uses rhesus macaques to model MAYV infection and transmission to Aedes aegypti mosquitoes, finding short viremia, low transmission rates, and limited mosquito infectivity.

Dose-dependent regulation of immune memory responses against HIV by saponin monophosphoryl lipid A nanoparticle adjuvant

This study evaluates the dose-dependent effects of the SMNP adjuvant on HIV Env-specific immune responses in non-human primates, showing increased memory T and B cell responses and neutralizing antibodies at higher doses.

Neuroanatomical abnormalities in a nonhuman primate model of congenital Zika virus infection

Macaque fetuses infected with Zika virus show both macro- and micro-scale neuropathological abnormalities, including decreased gyrencephality, relative increases in cortical white matter, activation of glia, and increased apoptosis.

Diversity and complexity of the large surface protein family in the compacted genomes of various Pneumocystis species

The paper characterizes the diversity and evolution of the Msg gene superfamily across Pneumocystis species, revealing its functional roles in immune evasion and host adaptation.