Regulation of transposons within medium spiny neurons enables molecular and behavioral responses to cocaine
Gabriella M. Silva, Joseph A. Picone, Amber L. Kaplan, Celeste R Park, Diego Piñeiro Lira, R. Kijoon Kim, Natalie L. Truby, Rachel L. Neve, Xiaohong Cui, Peter J. Hamilton
This study identifies ZFP189's role in regulating transposable elements in medium spiny neurons, showing how TE activation or repression in specific neuronal subtypes influences cocaine-related behaviors and gene expression.
bioRxiv · Aug 28, 2024 · PreprintNeuroscience