Elizabeth A. Heller

Systemic stress states are reversed by NPBWR1 inhibition

This study identifies chronic stress as a systemic molecular state across tissues in mice, showing that NPBWR1 inhibition reverses stress-related changes in multiple organs and sexes.

Neuron-specific epigenetic repression of Cdk5 impairs hippocampal-dependent memory in male and female mice

The paper shows that reducing Cdk5 gene expression via epigenetic editing impairs memory in both male and female mice, highlighting sex-independent epigenetic regulation of hippocampal memory.

Unexpected mechanisms of sex-specific memory vulnerabilities to acute traumatic stress

The paper investigates sex differences in memory vulnerability to acute traumatic stress, finding that estrogen and its receptors play a role in both males and females.

Hippocampal Cdk5 is regulated by distinct stress paradigms in male and female mice

The paper investigates sex-specific regulation of hippocampal Cdk5 in mice under different stress paradigms, finding male-specific changes in mRNA and protein levels under combined stress conditions.

Epigenetic editing of Cartpt promotes acquisition and extinction of cocaine memory

The paper uses CRISPR-based epigenetic editing to manipulate Cartpt expression in mice, showing it affects cocaine memory acquisition and extinction.

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

This paper demonstrates that CRISPR-mediated transcriptional activation can upregulate SYNGAP1 in a mouse model of SRID and human neurons, rescuing deficits without targeting mutations.

Corticosterone drives behavioral inflexibility via plasticity-related gene expression in the dorsal striatum

This study shows corticosterone reduces DMS synaptic plasticity genes and increases DLS ones, linking stress hormone effects to behavioral inflexibility in mice.

Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles

This study shows psilocybin enhances fear extinction by altering cortical neural ensembles, with acute suppression of fear-active neurons and delayed recruitment of extinction-active neurons.

MousiPLIER: A Mouse Pathway-Level Information Extractor Model

The paper introduces mousiPLIER, a mouse pathway-level information extractor model trained on brain RNA-seq data, which reduces dimensionality and identifies aging-related latent variables.

Mapping PTBP splicing in human brain identifies targets for therapeutic splice switching including SYNGAP1

Cell-Type Specific Profiling of Histone Post-Translational Modifications in the Adult Mouse Striatum

The paper profiles cell-type specific histone post-translational modifications in mouse striatal neurons to uncover regulatory epigenomic features associated with neurobiological function and disease.

Cocaine regulation of Nr4a1 chromatin bivalency and mRNA in male and female mice.

This study examines how cocaine affects Nr4a1 chromatin bivalency and mRNA levels in male and female mice across different brain regions.

Gain and loss of function variants in EZH1 disrupt neurogenesis timing and cause overlapping neurodevelopmental disorders

Set2-mediated alternative splicing of Srsf11 regulates cocaine reward behavior

This study shows that Set2-mediated H3K36me3 regulates alternative splicing of Srsf11, which influences cocaine reward behavior in mice.

Specific histone modifications associate with alternative exon selection during mammalian development

The paper identifies histone modifications associated with alternative exon selection during mammalian development using machine learning.