Human Bone Marrow Adipose Tissue is a Hematopoietic Niche for Leptin-DrivenMonopoiesis
Zinger Yang, Amruta Samant, Anand Desai, Tiffany DeSouza, Haley Cirka, Mai Ceesay, David M. Kostyra, Shannon Joyce, Lyne Khair, Javier Solivan-Rivera, Rachel Ziegler, Nathalia Ketelut Carneiro, Linus T Tsai, Michael A. Brehm, Louis M. Messina, , Tammy Nguyen
The paper identifies bone marrow adipose tissue as a hematopoietic niche that drives pro-inflammatory monocyte production via leptin signaling during aging.
bioRxiv · Aug 29, 2023 · PreprintDevelopmental Biology